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- W3089031455 abstract "Quadruple therapy using a single capsule formulation of bismuth, metronidazole and tetracycline (BMT; Pylera®), associated with omeprazole for the eradication of Helicobacter pylori, represents the reintroduction of bismuth in France after 40 years. To describe the real-life patterns of use of BMT following a request from the French health authorities. Patients with a first BMT dispensing (index date, ID), with one year of data before and after ID, were identified in the French nationwide claims database 1/97 sample. Misuse of BMT was defined as dispensing >1 pack of BMT at ID or absence of a diagnostic test in the preceding year. In total, 540 patients were included. Prescribers were gastroenterologists (n = 243; 45%) and general practitioners (n = 160; 30%). A proton pump inhibitor was co-dispensed to 504 patients (96%). Ten patients (2%) had contraindications to BMT. Fifty-nine patients (11%) met the misuse criteria: ten (2%) were dispensed > 1 pack of BMT and 49 (9%) had not had a diagnostic test for H. pylori in the previous year. During follow-up, 27 patients (5%) required retreatment (treatment failure). In this real-life study, most patients were dispensed only one pack of BMT, consistent with recommendations. Misuse related principally to the absence of prior diagnostic test for H. pylori." @default.
- W3089031455 created "2020-10-01" @default.
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- W3089031455 date "2020-09-01" @default.
- W3089031455 modified "2023-10-16" @default.
- W3089031455 title "Patterns of quadruple therapy use including bismuth for Helicobacter pylori eradication: A cohort study in the French national claims database" @default.
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- W3089031455 doi "https://doi.org/10.1016/j.therap.2020.09.002" @default.
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