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- W3089052748 abstract "The present study investigate the hepatoprotective and antioxidant effect of crude extract ofArctiumlappastem(E-ALS) and isolated total flavonoids(ITF) from the stem, With qualitative and quantitative determination of flavonoids by HPLC.Twenty four local adult male rabbitswere used in this study whichdivided into four groups(6animal in each group), Control-1(C1) as control group, Control-2(C2):treatedwith 300mg/kgparacetamoladministrated for one week, Group 1(G1): 300mg/kg paracetamol administratedfor one week +Orally 250mg/kg of E-ALSadministrated daily for 4 weeks, Group 2(G2): Orally 300mg/kgparacetamol administrated for one week +Orally 50mg/kg of ITFdministrated daily for 4 weeks.The results identified five types of flavonoids for the first time in plant stem (Rutin, Myricetin, Quercetin,Apigenin, Kaempferol) with quantified determination for the concentration of each type of flavonoids inE-ALS and also in ITF which identified the same five flavonoids. The hepatoprotective effect of E-ALS andITF were observed by monitoring the antioxidant parameters and activity of liver enzymes.The results obtained from this study showed that the levels of glutathione-GSH, Glutathione peroxidaseGPX and Glutathione-S-Transferase-GST were significantly (P ? 0.05) decreased in C2 treated withparacetamol as comparing with C1, with significant (P ? 0.05) elevation of alanine aminotransferase-ALT activity and non-significant effect on Aspartate aminotransferase-AST, while the level of GSH and GPX were significantly (P ? 0.05) elevated in G1 and G2 treated with E-ALS and ITF respectively as compared with C2, in which the levels of GSH and GPX are less than the levels in C1 and G1. Otherwise the levels ofGST, ALT and AST significantly (P ? 0.05) decreased in G1 and G2 as compared with C2. These findingsshow the hepatoprotective properties of E-ALS and IFT against liver injury induced by paracetmol and alsothe protective role of anti-oxidative defense system of flavonoids in the two extracts." @default.
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- W3089052748 date "2020-07-24" @default.
- W3089052748 modified "2023-09-29" @default.
- W3089052748 title "Isolation and Identification of Flavonoids from Arctiumlappa Stem and Study the Hepatoprotective Effecton Acetaminophen Induced Liver Damage" @default.
- W3089052748 doi "https://doi.org/10.37506/ijfmt.v14i3.10854" @default.
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