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• W3089057777 abstract "Sonic Hedgehog (Shh) and its patched-smoothened receptor complex control a variety of functions in the developing central nervous system such as neural cell proliferation and differentiation. Recently, Shh signaling components have been found to be expressed at the synaptic level in the postnatal brain, suggesting a potential role in the regulation of synaptic transmission. Using in utero electroporation of constitutively active and negative-phenotype forms of the Shh signal transducer smoothened (Smo), we studied the role of Smo signaling in the development and maturation of GABAergic transmission in the somatosensory cortex. Our results show that enhancing Smo activity during development accelerates the shift from depolarizing to hyperpolarizing GABA in dependence on functional expression of potassium-chloride cotransporter type 2 (KCC2). On the other hand, blocking Smo activity maintains GABA response in a depolarizing state in mature cortical neurons resulting in altered chloride homeostasis and increased seizure susceptibility. This study reveals an unexpected function of Smo signaling on the regulation of chloride homeostasis through the control of KCC2 cell surface stability and on the timing of the GABA inhibitory/excitatory shift in brain maturation." @default.
• W3089057777 created "2020-10-01" @default.
• W3089057777 creator A5005577568 @default.
• W3089057777 creator A5037547119 @default.
• W3089057777 creator A5046781760 @default.
• W3089057777 creator A5048290700 @default.
• W3089057777 creator A5050262277 @default.
• W3089057777 creator A5087099394 @default.
• W3089057777 creator A5090417920 @default.
• W3089057777 date "2020-01-01" @default.
• W3089057777 modified "2023-10-12" @default.
• W3089057777 title "Smoothened receptor Signaling regulates the developmental shift of GABA polarity in rat somatosensory cortex" @default.
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