FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3089061508> ?p ?o ?g. }

• W3089061508 endingPage "113416" @default.
• W3089061508 startingPage "113416" @default.
• W3089061508 abstract "Aristolochia indica L. (Aristolochiaceae) is a common medicinal plant described in many traditional medicine as well as in Ayurveda used against snakebites. Besides, the plant has also been reported traditionally against fever, rheumatic arthritis, madness, liver ailments, dyspepsia, oedema, leishmaniasis, leprosy, dysmenorrhoea, sexual diseases etc. The plant is known to contain its major bioactive constituent aristolochic acid (AA) known for its anti-snake venom, abortifacient, antimicrobial and antioxidant properties. This present work describes a validated, fast and reproducible high performance thin layer chromatography (HPTLC) method to estimate AA from the roots of 20 chemotypes of A. indica procured from 20 diverse geographical locations from the state of West Bengal, India. Further, an evidence-based approach was adopted to investigate the reported anti-venom activity of the aqueous extracts of the A. indica roots by assessing its phospholipase A2 (PLA2) inhibitory properties since PLA2 is a major component of many snake-venoms. Finally, the cytotoxicity and genotoxicity of the aqueous root extract of the Purulia (AI 1) chemotype were assessed at various concentrations using Allium cepa root meristematic cells. The highest amount of AA (7643.67 μg/g) was determined in the roots of A. indica chemotype collected from Purulia district followed by the chemotypes collected from Murshidabad, Jalpaiguri and Birbhum districts (7398.34, 7345.09 and 6809.97 μg/g respectively). This study not only determines AA in the plants to select pharmacologically elite chemotypes of A. indica, but it also identifies high AA producing A. indica for further domestication and propagation of the plants for pharmacological and industrial applications. The method was validated via analyzing inter-day and intra-day precision, repeatability, reproducibility, instrumental precision, limit of detection (LOD) and limit of quantification (LOQ) and specificity. Chemotypes with high AA content exhibited superior anti-PLA2 activity by selectively inhibiting human-group PLA2. Moreover, A. indica root extract significantly inhibited mitosis in Allium cepa root tips as a potent clastogen. The present quick, reproducible and validated HPTLC method provides an easy tool to determine AA in natural A. indica plant populations as well as in food and dietary supplements, a potential antivenin at one hand and a possible cause of aristolochic acid nephropathy (AAN) at another. Besides, the cytotoxic and mitotoxic properties of the root extracts should be used with caution especially for oral administration." @default.
• W3089061508 created "2020-10-01" @default.
• W3089061508 creator A5002254550 @default.
• W3089061508 creator A5029067326 @default.
• W3089061508 creator A5061778868 @default.
• W3089061508 creator A5075061338 @default.
• W3089061508 creator A5083105018 @default.
• W3089061508 date "2021-02-01" @default.
• W3089061508 modified "2023-09-30" @default.
• W3089061508 title "Chemotaxonomy of the ethnic antidote Aristolochia indica for aristolochic acid content: Implications of anti-phospholipase activity and genotoxicity study" @default.
• W3089061508 cites W1536289473 @default.
• W3089061508 cites W1605928876 @default.
• W3089061508 cites W1968731642 @default.
• W3089061508 cites W1977307953 @default.
• W3089061508 cites W1985503478 @default.
• W3089061508 cites W1987056475 @default.
• W3089061508 cites W1988055766 @default.
• W3089061508 cites W1991719156 @default.
• W3089061508 cites W1995439205 @default.
• W3089061508 cites W2004919674 @default.
• W3089061508 cites W2007595619 @default.
• W3089061508 cites W2007772430 @default.
• W3089061508 cites W2008914216 @default.
• W3089061508 cites W2012453964 @default.
• W3089061508 cites W2014488321 @default.
• W3089061508 cites W2015618104 @default.
• W3089061508 cites W2017843887 @default.
• W3089061508 cites W2019630454 @default.
• W3089061508 cites W2023363157 @default.
• W3089061508 cites W2030647947 @default.
• W3089061508 cites W2033089404 @default.
• W3089061508 cites W2049905588 @default.
• W3089061508 cites W2056097440 @default.
• W3089061508 cites W2080009393 @default.
• W3089061508 cites W2090119730 @default.
• W3089061508 cites W2093912586 @default.
• W3089061508 cites W2099925238 @default.
• W3089061508 cites W2104146696 @default.
• W3089061508 cites W2106592511 @default.
• W3089061508 cites W2108459140 @default.
• W3089061508 cites W2108599047 @default.
• W3089061508 cites W2127083610 @default.
• W3089061508 cites W2250227668 @default.
• W3089061508 cites W2278702378 @default.
• W3089061508 cites W2563584042 @default.
• W3089061508 cites W2609819738 @default.
• W3089061508 cites W2612722547 @default.
• W3089061508 cites W2744615124 @default.
• W3089061508 cites W2768557151 @default.
• W3089061508 cites W2896732147 @default.
• W3089061508 cites W2908946268 @default.
• W3089061508 cites W2911206294 @default.
• W3089061508 cites W2924693341 @default.
• W3089061508 cites W2942874030 @default.
• W3089061508 cites W2951319952 @default.
• W3089061508 cites W2967373307 @default.
• W3089061508 cites W2967659454 @default.
• W3089061508 cites W2969747281 @default.
• W3089061508 cites W2994853228 @default.
• W3089061508 cites W3001103123 @default.
• W3089061508 cites W3014504843 @default.
• W3089061508 cites W3091594913 @default.
• W3089061508 doi "https://doi.org/10.1016/j.jep.2020.113416" @default.
• W3089061508 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32980485" @default.
• W3089061508 hasPublicationYear "2021" @default.
• W3089061508 type Work @default.
• W3089061508 sameAs 3089061508 @default.
• W3089061508 citedByCount "10" @default.
• W3089061508 countsByYear W30890615082021 @default.
• W3089061508 countsByYear W30890615082022 @default.
• W3089061508 countsByYear W30890615082023 @default.
• W3089061508 crossrefType "journal-article" @default.
• W3089061508 hasAuthorship W3089061508A5002254550 @default.
• W3089061508 hasAuthorship W3089061508A5029067326 @default.
• W3089061508 hasAuthorship W3089061508A5061778868 @default.
• W3089061508 hasAuthorship W3089061508A5075061338 @default.
• W3089061508 hasAuthorship W3089061508A5083105018 @default.
• W3089061508 hasConcept C153784791 @default.
• W3089061508 hasConcept C178790620 @default.
• W3089061508 hasConcept C185592680 @default.
• W3089061508 hasConcept C2775837903 @default.
• W3089061508 hasConcept C2775943906 @default.
• W3089061508 hasConcept C2777155639 @default.
• W3089061508 hasConcept C2777278459 @default.
• W3089061508 hasConcept C2777993478 @default.
• W3089061508 hasConcept C2778959862 @default.
• W3089061508 hasConcept C2779158651 @default.
• W3089061508 hasConcept C2780813843 @default.
• W3089061508 hasConcept C29730261 @default.
• W3089061508 hasConcept C54355233 @default.
• W3089061508 hasConcept C556039675 @default.
• W3089061508 hasConcept C59822182 @default.
• W3089061508 hasConcept C71924100 @default.
• W3089061508 hasConcept C86803240 @default.
• W3089061508 hasConceptScore W3089061508C153784791 @default.
• W3089061508 hasConceptScore W3089061508C178790620 @default.
• W3089061508 hasConceptScore W3089061508C185592680 @default.
• W3089061508 hasConceptScore W3089061508C2775837903 @default.

• next