Matches in SemOpenAlex for { <https://semopenalex.org/work/W3089073486> ?p ?o ?g. }
- W3089073486 abstract "Summary Biotic and abiotic factors of wine fermentations have led to the accumulation of numerous genomic hallmarks of domestication in Saccharomyces cerevisiae wine strains. Here we have studied the paradoxical distribution of a dominant allele of IRC7 in wine yeast strains. This gene encodes a cysteine-S-β-lyase and presents two alleles: a wild full-length allele ( IRC7 F ) and a mutated one ( IRC7 S ), harboring a 38bp-deletion. Interestingly, IRC7 S -coding for a less active enzyme-appears in the great majority of wine strains. Studying its global distribution among phylogenetic clades, we observed that IRC7 S allele is dominant just in wine strains, having a moderate presence in other domesticated clades (Beer, Bread and Wine-PDM), but being completely absent in wild clades, appearing as a new hallmark of domestication. To explain this paradoxical distribution, we performed an IRC7 -rooted phenotypic-wide survey, demonstrating that IRC7 S -homozygous (HS) wine strains have both fitness (lower lag phases and higher growth rates) and competitive (killer toxin resistance, pseudohyphal growth) advantages. Hence, we performed a genome-wide survey across domesticated clades, finding a set of mutations that are conserved among wine strains and potentially associated to IRC7 S allele, which can help to explain the outstanding phenotype of HS strains and their dominant distribution in wines. Originality-Significance Statement S. cerevisiae is one of the best studied microbes due to its industrial importance and its use as a eukaryotic model organism. S. cerevisiae is also an interesting model for studying the effects of domestication in yeast genomic, phenotype and ecology. The study of how wild S. cerevisiae strains evolved into a greatly adapted domesticated strains and changed its lifestyle drastically is still of great interest. In the case of wine populations, strains have accumulated numerous hallmarks of domestication in their genome, related with their great phenotypic adaptation to this environment. Here, we report a new hallmark of domestication in wine strains; the IRC7 deleted allele ( IRC7 S ) and present the first insights about its unexpected global distribution among phylogenetic clades, understanding the genomic context and the phenotypic implications of this allele in wine strains." @default.
- W3089073486 created "2020-10-01" @default.
- W3089073486 creator A5009342040 @default.
- W3089073486 creator A5013366160 @default.
- W3089073486 creator A5013394238 @default.
- W3089073486 creator A5017066504 @default.
- W3089073486 creator A5018823490 @default.
- W3089073486 creator A5033547753 @default.
- W3089073486 creator A5041195714 @default.
- W3089073486 creator A5044710453 @default.
- W3089073486 creator A5048988929 @default.
- W3089073486 date "2020-09-24" @default.
- W3089073486 modified "2023-10-17" @default.
- W3089073486 title "New insights into the paradoxical distribution of<i>IRC7</i>in<i>Saccharomyces cerevisiae</i>and its associated phenotypic and genomic landscapes" @default.
- W3089073486 cites W1558695074 @default.
- W3089073486 cites W1907486465 @default.
- W3089073486 cites W1972770670 @default.
- W3089073486 cites W1975587955 @default.
- W3089073486 cites W1979319190 @default.
- W3089073486 cites W1979914496 @default.
- W3089073486 cites W1985016830 @default.
- W3089073486 cites W1986364415 @default.
- W3089073486 cites W1988458243 @default.
- W3089073486 cites W1991427331 @default.
- W3089073486 cites W1994163376 @default.
- W3089073486 cites W2005242762 @default.
- W3089073486 cites W2033405733 @default.
- W3089073486 cites W2039316942 @default.
- W3089073486 cites W2040773034 @default.
- W3089073486 cites W2052170867 @default.
- W3089073486 cites W2065932115 @default.
- W3089073486 cites W2081232002 @default.
- W3089073486 cites W2082001374 @default.
- W3089073486 cites W2083669318 @default.
- W3089073486 cites W2099902520 @default.
- W3089073486 cites W2106578986 @default.
- W3089073486 cites W2119180969 @default.
- W3089073486 cites W2120819924 @default.
- W3089073486 cites W2125910575 @default.
- W3089073486 cites W2127289300 @default.
- W3089073486 cites W2131271579 @default.
- W3089073486 cites W2144036514 @default.
- W3089073486 cites W2146403889 @default.
- W3089073486 cites W2149797789 @default.
- W3089073486 cites W2150071943 @default.
- W3089073486 cites W2170392103 @default.
- W3089073486 cites W2170665748 @default.
- W3089073486 cites W2290390365 @default.
- W3089073486 cites W2322239833 @default.
- W3089073486 cites W2410114410 @default.
- W3089073486 cites W2508506323 @default.
- W3089073486 cites W2529698121 @default.
- W3089073486 cites W2587852388 @default.
- W3089073486 cites W2590874532 @default.
- W3089073486 cites W2735992540 @default.
- W3089073486 cites W2740807504 @default.
- W3089073486 cites W2793203740 @default.
- W3089073486 cites W2798064943 @default.
- W3089073486 cites W2802083314 @default.
- W3089073486 cites W2883251903 @default.
- W3089073486 cites W2910607710 @default.
- W3089073486 cites W2914429608 @default.
- W3089073486 cites W2939600219 @default.
- W3089073486 cites W2987650093 @default.
- W3089073486 cites W2990427812 @default.
- W3089073486 cites W2992368140 @default.
- W3089073486 cites W2995372205 @default.
- W3089073486 cites W3103032866 @default.
- W3089073486 cites W4247053599 @default.
- W3089073486 doi "https://doi.org/10.1101/2020.09.24.307892" @default.
- W3089073486 hasPublicationYear "2020" @default.
- W3089073486 type Work @default.
- W3089073486 sameAs 3089073486 @default.
- W3089073486 citedByCount "0" @default.
- W3089073486 crossrefType "posted-content" @default.
- W3089073486 hasAuthorship W3089073486A5009342040 @default.
- W3089073486 hasAuthorship W3089073486A5013366160 @default.
- W3089073486 hasAuthorship W3089073486A5013394238 @default.
- W3089073486 hasAuthorship W3089073486A5017066504 @default.
- W3089073486 hasAuthorship W3089073486A5018823490 @default.
- W3089073486 hasAuthorship W3089073486A5033547753 @default.
- W3089073486 hasAuthorship W3089073486A5041195714 @default.
- W3089073486 hasAuthorship W3089073486A5044710453 @default.
- W3089073486 hasAuthorship W3089073486A5048988929 @default.
- W3089073486 hasBestOaLocation W30890734861 @default.
- W3089073486 hasConcept C104317684 @default.
- W3089073486 hasConcept C127716648 @default.
- W3089073486 hasConcept C134387633 @default.
- W3089073486 hasConcept C180754005 @default.
- W3089073486 hasConcept C2777576037 @default.
- W3089073486 hasConcept C2779222958 @default.
- W3089073486 hasConcept C31903555 @default.
- W3089073486 hasConcept C36442339 @default.
- W3089073486 hasConcept C54355233 @default.
- W3089073486 hasConcept C55952523 @default.
- W3089073486 hasConcept C86803240 @default.
- W3089073486 hasConceptScore W3089073486C104317684 @default.
- W3089073486 hasConceptScore W3089073486C127716648 @default.
- W3089073486 hasConceptScore W3089073486C134387633 @default.
- W3089073486 hasConceptScore W3089073486C180754005 @default.