FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3089075087> ?p ?o ?g. }

• W3089075087 endingPage "108864" @default.
• W3089075087 startingPage "108864" @default.
• W3089075087 abstract "Pseudorabies virus (PRV) is a prevalent and endemic swine pathogen that causes significant economic losses in the global swine industry. Due to the emergence of PRV mutant strains in recent years, vaccines can’t completely prevent and control PRV infection. Therefore, research and development of new vaccines and drugs with inhibitory effects on PRV are of great significance in the prevention and treatment of PR. In this study, we firstly screened a library of 44 FDA-approved drugs and found that hydroquinone (HQ) displayed high anti-PRV activity by inhibiting PRV adsorption onto and internalization into cells. This study revealed that hydroquinone treatment stimulated genes associated with the PI3K-AKT signal pathway. HQ increased AKT mRNA production and activated AKT phosphorylation in N2a cells. This finding suggests that HQ significantly inhibits PRV replication by activating the phosphorylation of AKT. We also conducted in vivo experiments in mice. Hydroquinone significantly reduced the viral loads in mouse tissues and the mortality after PRV infection. The above results indicate that hydroquinone significantly inhibits the replication of PRV mutant strain ZJ01 in ICR mice and has an inhibitory effect on PRV. This study will contribute to the development of a novel prophylactic and therapeutic strategy against PRV infection." @default.
• W3089075087 created "2020-10-01" @default.
• W3089075087 creator A5005602487 @default.
• W3089075087 creator A5019383992 @default.
• W3089075087 creator A5023104005 @default.
• W3089075087 creator A5045772958 @default.
• W3089075087 creator A5046668761 @default.
• W3089075087 creator A5084705624 @default.
• W3089075087 creator A5091209045 @default.
• W3089075087 date "2020-11-01" @default.
• W3089075087 modified "2023-10-13" @default.
• W3089075087 title "Hydroquinone inhibits PRV infection in neurons in vitro and in vivo" @default.
• W3089075087 cites W1532415610 @default.
• W3089075087 cites W1966315678 @default.
• W3089075087 cites W2018831724 @default.
• W3089075087 cites W2021766136 @default.
• W3089075087 cites W2031242404 @default.
• W3089075087 cites W2039237995 @default.
• W3089075087 cites W2060633931 @default.
• W3089075087 cites W2074053244 @default.
• W3089075087 cites W2075220919 @default.
• W3089075087 cites W2107705757 @default.
• W3089075087 cites W2121266203 @default.
• W3089075087 cites W2124605552 @default.
• W3089075087 cites W2136369768 @default.
• W3089075087 cites W2166875164 @default.
• W3089075087 cites W2256071216 @default.
• W3089075087 cites W2413475876 @default.
• W3089075087 cites W2494944008 @default.
• W3089075087 cites W2513750883 @default.
• W3089075087 cites W2557128243 @default.
• W3089075087 cites W2580480239 @default.
• W3089075087 cites W2594574412 @default.
• W3089075087 cites W2595184745 @default.
• W3089075087 cites W2609926006 @default.
• W3089075087 cites W2750942982 @default.
• W3089075087 cites W2765262977 @default.
• W3089075087 cites W2770911117 @default.
• W3089075087 cites W2791752420 @default.
• W3089075087 cites W2795578449 @default.
• W3089075087 cites W2889737768 @default.
• W3089075087 cites W2907407188 @default.
• W3089075087 cites W2937620930 @default.
• W3089075087 cites W2956133393 @default.
• W3089075087 cites W2972565123 @default.
• W3089075087 cites W4241938957 @default.
• W3089075087 doi "https://doi.org/10.1016/j.vetmic.2020.108864" @default.
• W3089075087 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33007606" @default.
• W3089075087 hasPublicationYear "2020" @default.
• W3089075087 type Work @default.
• W3089075087 sameAs 3089075087 @default.
• W3089075087 citedByCount "10" @default.
• W3089075087 countsByYear W30890750872021 @default.
• W3089075087 countsByYear W30890750872022 @default.
• W3089075087 countsByYear W30890750872023 @default.
• W3089075087 crossrefType "journal-article" @default.
• W3089075087 hasAuthorship W3089075087A5005602487 @default.
• W3089075087 hasAuthorship W3089075087A5019383992 @default.
• W3089075087 hasAuthorship W3089075087A5023104005 @default.
• W3089075087 hasAuthorship W3089075087A5045772958 @default.
• W3089075087 hasAuthorship W3089075087A5046668761 @default.
• W3089075087 hasAuthorship W3089075087A5084705624 @default.
• W3089075087 hasAuthorship W3089075087A5091209045 @default.
• W3089075087 hasConcept C11960822 @default.
• W3089075087 hasConcept C139770010 @default.
• W3089075087 hasConcept C140704245 @default.
• W3089075087 hasConcept C153911025 @default.
• W3089075087 hasConcept C159047783 @default.
• W3089075087 hasConcept C170493617 @default.
• W3089075087 hasConcept C202751555 @default.
• W3089075087 hasConcept C207001950 @default.
• W3089075087 hasConcept C2522874641 @default.
• W3089075087 hasConcept C54355233 @default.
• W3089075087 hasConcept C55493867 @default.
• W3089075087 hasConcept C75217442 @default.
• W3089075087 hasConcept C86803240 @default.
• W3089075087 hasConcept C89423630 @default.
• W3089075087 hasConcept C95444343 @default.
• W3089075087 hasConceptScore W3089075087C11960822 @default.
• W3089075087 hasConceptScore W3089075087C139770010 @default.
• W3089075087 hasConceptScore W3089075087C140704245 @default.
• W3089075087 hasConceptScore W3089075087C153911025 @default.
• W3089075087 hasConceptScore W3089075087C159047783 @default.
• W3089075087 hasConceptScore W3089075087C170493617 @default.
• W3089075087 hasConceptScore W3089075087C202751555 @default.
• W3089075087 hasConceptScore W3089075087C207001950 @default.
• W3089075087 hasConceptScore W3089075087C2522874641 @default.
• W3089075087 hasConceptScore W3089075087C54355233 @default.
• W3089075087 hasConceptScore W3089075087C55493867 @default.
• W3089075087 hasConceptScore W3089075087C75217442 @default.
• W3089075087 hasConceptScore W3089075087C86803240 @default.
• W3089075087 hasConceptScore W3089075087C89423630 @default.
• W3089075087 hasConceptScore W3089075087C95444343 @default.
• W3089075087 hasFunder F4320321001 @default.
• W3089075087 hasFunder F4320335777 @default.
• W3089075087 hasFunder F4320335787 @default.
• W3089075087 hasLocation W30890750871 @default.
• W3089075087 hasOpenAccess W3089075087 @default.

• next