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- W3089079819 abstract "Abstract Neurotransmitter (NT) abnormalities in the enteric nervous system have been reported as crucial roles to regulate the intestinal inflammation and gut immune homeostasis. Capturing quantitative changes at the NT metabolome provides an opportunity to develop an understanding of neuroimmune-mediated inflammation. Given the wide diversity of chemical characterizations in the NTs, only partial coverage of the NT metabolome can be simultaneously quantified in a single-run analysis. Herein, we summarized the distribution of functional groups of compound entries in the NT metabolome. Based on this information, an orthogonal dansyl-labeling and label-free dual pretreatment approach was separately designed to target phenol and amine NTs and tertiary amine and choline NTs. By combining the dansyl-labeled and unlabeled NTs within a single vial, a comprehensive and practical approach was optimized for quantifying high coverage of NT metabolome in a single-run analysis on the reversed-phase C18 column. Method validation indicated good linearity with correlation coefficients (R2) > 0.99, intra- and interday accuracy with relative error" @default.
- W3089079819 created "2020-10-01" @default.
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- W3089079819 date "2020-12-01" @default.
- W3089079819 modified "2023-09-24" @default.
- W3089079819 title "Orthogonal label and label-free dual pretreatment for targeted profiling of neurotransmitters in enteric nervous system" @default.
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- W3089079819 doi "https://doi.org/10.1016/j.aca.2020.09.031" @default.
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