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- W3089082173 abstract "Abstract The pluripotency factor Oct4 is essential for the maintenance of naïve pluripotent stem cells in vitro and in vivo. However, the specific role of Oct4 in this process remains unknown. Here, we developed a rapid protein-level Oct4 depletion system that demonstrates that the immediate downstream response to loss of Oct4 is reduced expression of key pluripotency factors. Our data show a requirement for Oct4 for the efficient transcription of several key pluripotency factors, and suggest that expression of trophectoderm markers is a subsequent event. Additionally, we find that Nanog is competent to bind to the genome in the absence of Oct4, and this binding is in fact enhanced. Globally, however, active enhancer associated histone mark H3K27ac is depleted. Our work establishes that while Oct4 is required for the maintenance of the naïve transcription factor network, at a normal ESC level it antagonises this network through inhibition of Nanog binding." @default.
- W3089082173 created "2020-10-01" @default.
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- W3089082173 date "2020-09-22" @default.
- W3089082173 modified "2023-09-26" @default.
- W3089082173 title "Auxin-degron system identifies immediate mechanisms of Oct4" @default.
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- W3089082173 doi "https://doi.org/10.1101/2020.09.21.306241" @default.
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