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• W3089088100 abstract "<ns4:p><ns4:bold>Background: </ns4:bold>Low-complexity regions (LCRs) on proteins have attracted increasing attention recently due to their role in the assembly of membraneless organelles or granules by liquid-liquid phase separation. Several examples of such granules have been shown to sequester RNA and proteins in an inactive state, providing an important mechanism for dynamic post-transcriptional gene regulation. In trypanosome parasites, post-transcriptional control overwhelmingly dominates gene regulation due to the organisation of their genome into polycistronic transcription units. The purpose of the current study was to generate a substantially more comprehensive genome-wide survey of LCRs on trypanosome proteins than currently available <ns4:italic>. </ns4:italic></ns4:p><ns4:p> <ns4:bold>Methods: </ns4:bold>Using the Shannon’s entropy method, provided in the R package ‘entropy’, we identified LCRs in the proteome of <ns4:italic>Trypanosoma brucei</ns4:italic>. Our analysis predicts LCRs and their positional enrichment in distinct protein cohorts and superimposes on this a range of post-translational modifications derived from available experimental datasets.</ns4:p><ns4:p> <ns4:bold>Results: </ns4:bold>We have identified 8162 LCRs present on 4914 proteins, representing 42% of the proteome, placing <ns4:italic>Trypanosoma brucei</ns4:italic> among the eukaryotes with the highest percentage of LCRs<ns4:italic>.</ns4:italic> Our results highlight the enrichment of LCRs in the C-terminal region of predicted nucleic acid binding proteins, these acting as favoured sites for potential phosphorylation. Phosphorylation represents 51% of the post-translational modifications present on LCRs compared to 16% on the rest of the proteome.</ns4:p><ns4:p> <ns4:bold>Conclusions: </ns4:bold>The post-translational modifications of LCRs, and in particular phosphorylation events, could contribute to post-transcriptional gene expression control and the dynamics of protein targeting to membraneless organelles in kinetoplastid parasites.</ns4:p>" @default.
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• W3089088100 date "2020-11-18" @default.
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• W3089088100 title "A global analysis of low-complexity regions in the Trypanosoma brucei proteome reveals enrichment in the C-terminus of nucleic acid binding proteins providing potential targets of phosphorylation" @default.
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• W3089088100 doi "https://doi.org/10.12688/wellcomeopenres.16286.2" @default.
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