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- W3089094196 abstract "We read with interest the report by Nagesh Kalakonda and colleagues of the SADAL trial 1 Kalakonda N Maerevoet M Cavallo F et al. Selinexor in patients with relapsed or refractory diffuse large B-cell lymphoma (SADAL): a single-arm, multinational, multicentre, open-label, phase 2 trial. Lancet Haematol. 2020; 7: e511-e522 Summary Full Text Full Text PDF PubMed Scopus (133) Google Scholar of selinexor for relapsed or refractory diffuse large B-cell lymphoma (DLBCL). The novel mechanism of selinexor and the 15 (12%) complete responses observed in 127 patients in the study suggest that the drug could be promising in certain subgroups of patients with relapsed or refractory DLBCL. However, the subgroups that are likely to benefit remain to be identified, and the SADAL population might not be representative of all patients with relapsed or refractory DLBCL. Selinexor in patients with relapsed or refractory diffuse large B-cell lymphoma (SADAL): a single-arm, multinational, multicentre, open-label, phase 2 trialSingle-drug oral selinexor induced durable responses and had a manageable adverse events profile in patients with relapsed or refractory DLBCL who received at least two lines of previous chemoimmunotherapy. Selinexor could be considered a new oral, non-cytotoxic treatment option in this setting. Full-Text PDF Selinexor for relapsed or refractory diffuse large B-cell lymphoma: examining the artifact – Authors' replyIn response to the Correspondence from Stephen Smith and Ajay Gopal, we contend that the patients enrolled in the SADAL trial1 were not atypical of patients with relapsed or refractory diffuse large B-cell lymphoma (DLBCL). This contention is best supported by the finding that the median overall survival time of patients with progressive disease or a non-evaluable response was 4·3 months (95% CI 3·0–5·4). This time is shorter than what was anticipated on the basis of data from the SCHOLAR-1 study,2 which showed median overall survival times of around 5–6 months across cohorts of patients with relapsed or refractory DLBCL. Full-Text PDF" @default.
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- W3089094196 date "2020-10-01" @default.
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- W3089094196 title "Selinexor for relapsed or refractory diffuse large B-cell lymphoma: examining the artifact" @default.
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- W3089094196 doi "https://doi.org/10.1016/s2352-3026(20)30290-8" @default.
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