Matches in SemOpenAlex for { <https://semopenalex.org/work/W3089118907> ?p ?o ?g. }
- W3089118907 endingPage "168" @default.
- W3089118907 startingPage "154" @default.
- W3089118907 abstract "Yes-associated protein (YAP) and TAZ (WW domain containing transcription regulator 1, or WWTR1) are paralog transcriptional regulators, able to integrate mechanical, metabolic, and signaling inputs to regulate cell growth and differentiation during development and neoplastic progression. YAP and TAZ hold common and distinctive structural features, reflecting only partially overlapping regulatory mechanisms. The two paralogs interact with both shared and specific transcriptional partners and control nonidentical transcriptional programs. Although most of the available literature considers YAP and TAZ as functionally redundant, they play distinctive or even contrasting roles in different contexts. The issue of their divergent roles is currently underexplored but holds fundamental implications for mechanistic and translational studies. Here, we aim to review the available literature on the biological functions of YAP and TAZ, highlighting differential roles that distinguish these two paralogues." @default.
- W3089118907 created "2020-10-01" @default.
- W3089118907 creator A5014045886 @default.
- W3089118907 creator A5032014419 @default.
- W3089118907 creator A5060017642 @default.
- W3089118907 creator A5089969449 @default.
- W3089118907 date "2021-02-01" @default.
- W3089118907 modified "2023-10-18" @default.
- W3089118907 title "YAP and TAZ Are Not Identical Twins" @default.
- W3089118907 cites W1907833971 @default.
- W3089118907 cites W1925728463 @default.
- W3089118907 cites W1949381744 @default.
- W3089118907 cites W1957918071 @default.
- W3089118907 cites W1980236812 @default.
- W3089118907 cites W1982498121 @default.
- W3089118907 cites W1986676916 @default.
- W3089118907 cites W1987049707 @default.
- W3089118907 cites W1990324370 @default.
- W3089118907 cites W1991226174 @default.
- W3089118907 cites W1995160678 @default.
- W3089118907 cites W1997973068 @default.
- W3089118907 cites W2000121424 @default.
- W3089118907 cites W2003044806 @default.
- W3089118907 cites W2006548076 @default.
- W3089118907 cites W2007916618 @default.
- W3089118907 cites W2017344623 @default.
- W3089118907 cites W2022423243 @default.
- W3089118907 cites W2023775321 @default.
- W3089118907 cites W2027150010 @default.
- W3089118907 cites W2028933149 @default.
- W3089118907 cites W2030433725 @default.
- W3089118907 cites W2034469841 @default.
- W3089118907 cites W2038438556 @default.
- W3089118907 cites W2038441458 @default.
- W3089118907 cites W2040430549 @default.
- W3089118907 cites W2042635844 @default.
- W3089118907 cites W2047613966 @default.
- W3089118907 cites W2047757959 @default.
- W3089118907 cites W2056102163 @default.
- W3089118907 cites W2061058076 @default.
- W3089118907 cites W2073157874 @default.
- W3089118907 cites W2074124948 @default.
- W3089118907 cites W2075452487 @default.
- W3089118907 cites W2085039090 @default.
- W3089118907 cites W2085197940 @default.
- W3089118907 cites W2086332492 @default.
- W3089118907 cites W2098532354 @default.
- W3089118907 cites W2098692163 @default.
- W3089118907 cites W2100842035 @default.
- W3089118907 cites W2105616338 @default.
- W3089118907 cites W2109682960 @default.
- W3089118907 cites W2113037810 @default.
- W3089118907 cites W2123511906 @default.
- W3089118907 cites W2126712555 @default.
- W3089118907 cites W2127240308 @default.
- W3089118907 cites W2134956953 @default.
- W3089118907 cites W2139746915 @default.
- W3089118907 cites W2140381750 @default.
- W3089118907 cites W2146337514 @default.
- W3089118907 cites W2151260549 @default.
- W3089118907 cites W2153038369 @default.
- W3089118907 cites W2153665127 @default.
- W3089118907 cites W2154835619 @default.
- W3089118907 cites W2159310898 @default.
- W3089118907 cites W2160674488 @default.
- W3089118907 cites W2160778199 @default.
- W3089118907 cites W2161616384 @default.
- W3089118907 cites W2162730852 @default.
- W3089118907 cites W2169073108 @default.
- W3089118907 cites W2169110374 @default.
- W3089118907 cites W2200414333 @default.
- W3089118907 cites W2228198088 @default.
- W3089118907 cites W2326005020 @default.
- W3089118907 cites W2327188447 @default.
- W3089118907 cites W2336961991 @default.
- W3089118907 cites W2426003472 @default.
- W3089118907 cites W2577679015 @default.
- W3089118907 cites W2603000633 @default.
- W3089118907 cites W2603296898 @default.
- W3089118907 cites W2610870630 @default.
- W3089118907 cites W2612611322 @default.
- W3089118907 cites W2623586343 @default.
- W3089118907 cites W2737033892 @default.
- W3089118907 cites W2742951203 @default.
- W3089118907 cites W2743161371 @default.
- W3089118907 cites W2766200583 @default.
- W3089118907 cites W2782258386 @default.
- W3089118907 cites W2787222113 @default.
- W3089118907 cites W2803848728 @default.
- W3089118907 cites W2890361765 @default.
- W3089118907 cites W2896904866 @default.
- W3089118907 cites W2898723593 @default.
- W3089118907 cites W2902481648 @default.
- W3089118907 cites W2912128540 @default.
- W3089118907 cites W2936731687 @default.
- W3089118907 cites W2942643945 @default.
- W3089118907 cites W2967319134 @default.
- W3089118907 cites W2971708908 @default.