Matches in SemOpenAlex for { <https://semopenalex.org/work/W3089166089> ?p ?o ?g. }
- W3089166089 endingPage "2765" @default.
- W3089166089 startingPage "2765" @default.
- W3089166089 abstract "In preclinical cancer research, three-dimensional (3D) cell culture systems such as multicellular spheroids and organoids are becoming increasingly important. They provide valuable information before studies on animal models begin and, in some cases, are even suitable for reducing or replacing animal experiments. Furthermore, they recapitulate microtumors, metastases, and the tumor microenvironment much better than monolayer culture systems could. Three-dimensional models show higher structural complexity and diverse cell interactions while reflecting (patho)physiological phenomena such as oxygen and nutrient gradients in the course of their growth or development. These interactions and properties are of great importance for understanding the pathophysiological importance of stromal cells and the extracellular matrix for tumor progression, treatment response, or resistance mechanisms of solid tumors. Special emphasis is placed on co-cultivation with tumor-associated cells, which further increases the predictive value of 3D models, e.g., for drug development. The aim of this overview is to shed light on selected 3D models and their advantages and disadvantages, especially from the radiopharmacist’s point of view with focus on the suitability of 3D models for the radiopharmacological characterization of novel radiotracers and radiotherapeutics. Special attention is paid to pancreatic ductal adenocarcinoma (PDAC) as a predestined target for the development of new radionuclide-based theranostics." @default.
- W3089166089 created "2020-10-01" @default.
- W3089166089 creator A5004943703 @default.
- W3089166089 creator A5016501548 @default.
- W3089166089 creator A5077562986 @default.
- W3089166089 creator A5086741053 @default.
- W3089166089 creator A5091617096 @default.
- W3089166089 date "2020-09-25" @default.
- W3089166089 modified "2023-10-06" @default.
- W3089166089 title "Three-Dimensional Cell Culture Systems in Radiopharmaceutical Cancer Research" @default.
- W3089166089 cites W1483496013 @default.
- W3089166089 cites W1484585927 @default.
- W3089166089 cites W1575512771 @default.
- W3089166089 cites W1579189600 @default.
- W3089166089 cites W1599096704 @default.
- W3089166089 cites W1601895606 @default.
- W3089166089 cites W1808138581 @default.
- W3089166089 cites W1819470723 @default.
- W3089166089 cites W1829445575 @default.
- W3089166089 cites W1837090400 @default.
- W3089166089 cites W1842167960 @default.
- W3089166089 cites W1926518917 @default.
- W3089166089 cites W1936227058 @default.
- W3089166089 cites W1964528827 @default.
- W3089166089 cites W1967020236 @default.
- W3089166089 cites W1969803714 @default.
- W3089166089 cites W1975447309 @default.
- W3089166089 cites W1977549111 @default.
- W3089166089 cites W1978148663 @default.
- W3089166089 cites W1978282308 @default.
- W3089166089 cites W1980828565 @default.
- W3089166089 cites W1981684516 @default.
- W3089166089 cites W1984242958 @default.
- W3089166089 cites W1985204475 @default.
- W3089166089 cites W1985804036 @default.
- W3089166089 cites W1991102099 @default.
- W3089166089 cites W1994320675 @default.
- W3089166089 cites W1994435943 @default.
- W3089166089 cites W1994524105 @default.
- W3089166089 cites W1995143361 @default.
- W3089166089 cites W1995793981 @default.
- W3089166089 cites W2002222671 @default.
- W3089166089 cites W2004736165 @default.
- W3089166089 cites W2010360032 @default.
- W3089166089 cites W2010916968 @default.
- W3089166089 cites W2011787586 @default.
- W3089166089 cites W2019678937 @default.
- W3089166089 cites W2020721418 @default.
- W3089166089 cites W2023894812 @default.
- W3089166089 cites W2024050967 @default.
- W3089166089 cites W2025183054 @default.
- W3089166089 cites W2026632078 @default.
- W3089166089 cites W2027993536 @default.
- W3089166089 cites W2029689067 @default.
- W3089166089 cites W2035179295 @default.
- W3089166089 cites W2035479043 @default.
- W3089166089 cites W2036200411 @default.
- W3089166089 cites W2036663362 @default.
- W3089166089 cites W2036730957 @default.
- W3089166089 cites W2037827070 @default.
- W3089166089 cites W2038935943 @default.
- W3089166089 cites W2043156676 @default.
- W3089166089 cites W2043186407 @default.
- W3089166089 cites W2043894553 @default.
- W3089166089 cites W2045387133 @default.
- W3089166089 cites W2045462226 @default.
- W3089166089 cites W2045774540 @default.
- W3089166089 cites W2046878349 @default.
- W3089166089 cites W2048116946 @default.
- W3089166089 cites W2050698012 @default.
- W3089166089 cites W2050859161 @default.
- W3089166089 cites W2050910055 @default.
- W3089166089 cites W2055632192 @default.
- W3089166089 cites W2064895890 @default.
- W3089166089 cites W2068041621 @default.
- W3089166089 cites W2073946113 @default.
- W3089166089 cites W2075296270 @default.
- W3089166089 cites W2076921551 @default.
- W3089166089 cites W2084904115 @default.
- W3089166089 cites W2086557921 @default.
- W3089166089 cites W2086788386 @default.
- W3089166089 cites W2087554862 @default.
- W3089166089 cites W2093080620 @default.
- W3089166089 cites W2094108414 @default.
- W3089166089 cites W2096201476 @default.
- W3089166089 cites W2099069796 @default.
- W3089166089 cites W2101487088 @default.
- W3089166089 cites W2102478637 @default.
- W3089166089 cites W2104416279 @default.
- W3089166089 cites W2104871302 @default.
- W3089166089 cites W2105017561 @default.
- W3089166089 cites W2106224949 @default.
- W3089166089 cites W2108126466 @default.
- W3089166089 cites W2113574884 @default.
- W3089166089 cites W2113648694 @default.
- W3089166089 cites W2114229735 @default.
- W3089166089 cites W2116475082 @default.
- W3089166089 cites W2119698183 @default.