Matches in SemOpenAlex for { <https://semopenalex.org/work/W3089173739> ?p ?o ?g. }
Showing items 1 to 90 of
90
with 100 items per page.
- W3089173739 endingPage "26" @default.
- W3089173739 startingPage "19" @default.
- W3089173739 abstract "Background It can be challenging to recognize undifferentiated/immature ganglion cells, especially single forms. Ganglion cells and glia are derived from enteric neural crest cells (ENCCs), a group of autonomic nervous system (ANS)-lineage neural crest progenitors that PHOX2B regulates. Phox2b is an excellent marker for neoplastic and non-neoplastic ANS cells (eg, peripheral neuroblastic tumors [pNTs]). We hypothesized that Phox2b immunohistochemical staining (IHC) would also be useful for detecting ENCCs. Methods Hematoxylin and eosin, calretinin IHC, and Phox2b IHC were reviewed on 21 pull-through specimens and on a cohort of 12 rectal biopsies. Results Phox2b IHC demonstrated nuclear positivity in all of the ganglion cells across the different phases of differentiation without background staining. The Phox2b result correlated with the morphological findings, calretinin IHC results, and diagnoses based on the routine diagnostic method. The intensity was uniformly strong in the undifferentiated/immature forms and became variable in the mature forms; this pattern was similar to that seen in pNTs. Conclusion Phox2b IHC was highly sensitive and specific for detecting ganglion cells. It worked especially well for immature ganglion cells, seen in premature neonates, and scattered single forms in transition zones. In basic research settings, Phox2b can be a useful marker for early differentiation of ENCCs." @default.
- W3089173739 created "2020-10-01" @default.
- W3089173739 creator A5008062900 @default.
- W3089173739 creator A5016024659 @default.
- W3089173739 creator A5060072292 @default.
- W3089173739 creator A5074702551 @default.
- W3089173739 creator A5084506130 @default.
- W3089173739 date "2020-09-25" @default.
- W3089173739 modified "2023-09-26" @default.
- W3089173739 title "Phox2b Immunohistochemical Staining in Detecting Enteric Neural Crest Cells in Hirschsprung Disease" @default.
- W3089173739 cites W1570458334 @default.
- W3089173739 cites W1980950734 @default.
- W3089173739 cites W1984838392 @default.
- W3089173739 cites W2020493895 @default.
- W3089173739 cites W2023271687 @default.
- W3089173739 cites W2044061154 @default.
- W3089173739 cites W2067083357 @default.
- W3089173739 cites W2103260738 @default.
- W3089173739 cites W2161254422 @default.
- W3089173739 cites W2507724550 @default.
- W3089173739 cites W2570429698 @default.
- W3089173739 cites W2761583002 @default.
- W3089173739 cites W2991754063 @default.
- W3089173739 cites W986369232 @default.
- W3089173739 doi "https://doi.org/10.1177/1093526620953372" @default.
- W3089173739 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32975470" @default.
- W3089173739 hasPublicationYear "2020" @default.
- W3089173739 type Work @default.
- W3089173739 sameAs 3089173739 @default.
- W3089173739 citedByCount "2" @default.
- W3089173739 countsByYear W30891737392022 @default.
- W3089173739 crossrefType "journal-article" @default.
- W3089173739 hasAuthorship W3089173739A5008062900 @default.
- W3089173739 hasAuthorship W3089173739A5016024659 @default.
- W3089173739 hasAuthorship W3089173739A5060072292 @default.
- W3089173739 hasAuthorship W3089173739A5074702551 @default.
- W3089173739 hasAuthorship W3089173739A5084506130 @default.
- W3089173739 hasConcept C105702510 @default.
- W3089173739 hasConcept C125473707 @default.
- W3089173739 hasConcept C126749454 @default.
- W3089173739 hasConcept C142724271 @default.
- W3089173739 hasConcept C169760540 @default.
- W3089173739 hasConcept C196843134 @default.
- W3089173739 hasConcept C204232928 @default.
- W3089173739 hasConcept C2777439022 @default.
- W3089173739 hasConcept C2779089422 @default.
- W3089173739 hasConcept C2779134260 @default.
- W3089173739 hasConcept C2781334511 @default.
- W3089173739 hasConcept C2781404787 @default.
- W3089173739 hasConcept C71924100 @default.
- W3089173739 hasConcept C74864618 @default.
- W3089173739 hasConcept C86803240 @default.
- W3089173739 hasConcept C95444343 @default.
- W3089173739 hasConceptScore W3089173739C105702510 @default.
- W3089173739 hasConceptScore W3089173739C125473707 @default.
- W3089173739 hasConceptScore W3089173739C126749454 @default.
- W3089173739 hasConceptScore W3089173739C142724271 @default.
- W3089173739 hasConceptScore W3089173739C169760540 @default.
- W3089173739 hasConceptScore W3089173739C196843134 @default.
- W3089173739 hasConceptScore W3089173739C204232928 @default.
- W3089173739 hasConceptScore W3089173739C2777439022 @default.
- W3089173739 hasConceptScore W3089173739C2779089422 @default.
- W3089173739 hasConceptScore W3089173739C2779134260 @default.
- W3089173739 hasConceptScore W3089173739C2781334511 @default.
- W3089173739 hasConceptScore W3089173739C2781404787 @default.
- W3089173739 hasConceptScore W3089173739C71924100 @default.
- W3089173739 hasConceptScore W3089173739C74864618 @default.
- W3089173739 hasConceptScore W3089173739C86803240 @default.
- W3089173739 hasConceptScore W3089173739C95444343 @default.
- W3089173739 hasIssue "1" @default.
- W3089173739 hasLocation W30891737391 @default.
- W3089173739 hasOpenAccess W3089173739 @default.
- W3089173739 hasPrimaryLocation W30891737391 @default.
- W3089173739 hasRelatedWork W100944166 @default.
- W3089173739 hasRelatedWork W1730921909 @default.
- W3089173739 hasRelatedWork W2083985793 @default.
- W3089173739 hasRelatedWork W2163828550 @default.
- W3089173739 hasRelatedWork W2365674884 @default.
- W3089173739 hasRelatedWork W2548357598 @default.
- W3089173739 hasRelatedWork W2946110977 @default.
- W3089173739 hasRelatedWork W3089173739 @default.
- W3089173739 hasRelatedWork W3142816249 @default.
- W3089173739 hasRelatedWork W2049504968 @default.
- W3089173739 hasVolume "24" @default.
- W3089173739 isParatext "false" @default.
- W3089173739 isRetracted "false" @default.
- W3089173739 magId "3089173739" @default.
- W3089173739 workType "article" @default.