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- W3089180610 abstract "Purpose: The aim of this study was to evaluate the effect of switching from aflibercept toranibizumab in patients with aflibercept refractory neovascular age-related maculardegeneration (nAMD) and to identify predictive factors for switch response.Methods: Retrospective chart review including eyes with nAMD, refractory to monthlyintravitreal aflibercept during 6 months or more and that were switched to ranibizumab.Outcome measures included changes in visual acuity (VA), intra- (IRF) and subretinal fluid(SRF), pigment epithelial detachment (PED) and central retinal thickness (CRT), evaluated at6 months before switch (T1), at the switching timepoint (T2), and 3 months post-switch (T3).Results: The study included 32 eyes from 26 patients. There was an increase of CRT fromT1 to T2, which decreased after switch from T2 to T3. Evaluating the differentcompartments, a significant slope (change per month before and after switching) changewas found for PED height (p=0.02), for the subretinal fluid (p=0.01) and for the neuroretinalthickness as a measure for intraretinal fluid (p=0.03). No significant change was found forVA. Predictive factors for better morphological switch response included a steeper slopebefore switch (worsening between T1 to T2), thicker measurement of the parameter at T2,male gender, shorter treatment before switch and fewer preceding injections. Noassociation with preceding switch was found.Conclusion: Aflibercept-refractory nAMD benefits from switching to ranibizumab,particularly in cases of preceding worsening. Drug tolerance to aflibercept is suspectedresponsible. Thus, appropriate clinical decision might be facilitated by this knowledge,supposedly with a visual benefit for the patients." @default.
- W3089180610 created "2020-10-01" @default.
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- W3089180610 date "2019-01-01" @default.
- W3089180610 modified "2023-09-27" @default.
- W3089180610 title "Aflibercept-Refractory Neovascular Age-related Macular Degeneration: Response to Switching to Ranibizumab" @default.
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