Matches in SemOpenAlex for { <https://semopenalex.org/work/W3089188356> ?p ?o ?g. }
- W3089188356 endingPage "2932" @default.
- W3089188356 startingPage "2932" @default.
- W3089188356 abstract "Obesity and obesity-related disorders, such as type 2 diabetes have been progressively increasing worldwide and treatments have failed to counteract their progression. Growing evidence have demonstrated that gut microbiota is associated with the incidence of these pathologies. Hence, the identification of new nutritional compounds, able to improve health through a modulation of gut microbiota, is gaining interest. In this context, the aim of this study was to investigate the gut-driving effects of rhubarb extract in a context of diet-induced obesity and diabetes. Eight weeks old C57BL6/J male mice were fed a control diet (CTRL), a high fat and high sucrose diet (HFHS) or a HFHS diet supplemented with 0.3% (g/g) of rhubarb extract for eight weeks. Rhubarb supplementation fully prevented HFHS-induced obesity, diabetes, visceral adiposity, adipose tissue inflammation and liver triglyceride accumulation, without any modification in food intake. By combining sequencing and qPCR methods, we found that all these effects were associated with a blooming of Akkermansia muciniphila, which is strongly correlated with increased expression of Reg3γ in the colon. Our data showed that rhubarb supplementation is sufficient to protect against metabolic disorders induced by a diet rich in lipid and carbohydrates in association with a reciprocal interaction between Akkermansia muciniphila and Reg3γ." @default.
- W3089188356 created "2020-10-01" @default.
- W3089188356 creator A5005119625 @default.
- W3089188356 creator A5007768979 @default.
- W3089188356 creator A5029648123 @default.
- W3089188356 creator A5042192451 @default.
- W3089188356 creator A5048758178 @default.
- W3089188356 creator A5064103224 @default.
- W3089188356 creator A5070336660 @default.
- W3089188356 creator A5079487846 @default.
- W3089188356 creator A5084903539 @default.
- W3089188356 creator A5085161505 @default.
- W3089188356 date "2020-09-24" @default.
- W3089188356 modified "2023-09-26" @default.
- W3089188356 title "Rhubarb Supplementation Prevents Diet-Induced Obesity and Diabetes in Association with Increased Akkermansia muciniphila in Mice" @default.
- W3089188356 cites W1254022929 @default.
- W3089188356 cites W1952994333 @default.
- W3089188356 cites W1966210135 @default.
- W3089188356 cites W1976725370 @default.
- W3089188356 cites W1977475597 @default.
- W3089188356 cites W1983595568 @default.
- W3089188356 cites W1984167160 @default.
- W3089188356 cites W1991481679 @default.
- W3089188356 cites W2003342633 @default.
- W3089188356 cites W2011848880 @default.
- W3089188356 cites W2024678791 @default.
- W3089188356 cites W2027633471 @default.
- W3089188356 cites W2032782331 @default.
- W3089188356 cites W2034007873 @default.
- W3089188356 cites W2047315849 @default.
- W3089188356 cites W2047481286 @default.
- W3089188356 cites W2048853985 @default.
- W3089188356 cites W2051993213 @default.
- W3089188356 cites W2056749772 @default.
- W3089188356 cites W2059439508 @default.
- W3089188356 cites W2070172494 @default.
- W3089188356 cites W2070745109 @default.
- W3089188356 cites W2072537291 @default.
- W3089188356 cites W2077590888 @default.
- W3089188356 cites W2078721766 @default.
- W3089188356 cites W2080866840 @default.
- W3089188356 cites W2081075620 @default.
- W3089188356 cites W2083501377 @default.
- W3089188356 cites W2097099115 @default.
- W3089188356 cites W2097351547 @default.
- W3089188356 cites W2099456560 @default.
- W3089188356 cites W2108150441 @default.
- W3089188356 cites W2114110707 @default.
- W3089188356 cites W2114821999 @default.
- W3089188356 cites W2115496765 @default.
- W3089188356 cites W2116647894 @default.
- W3089188356 cites W2117065897 @default.
- W3089188356 cites W2129917444 @default.
- W3089188356 cites W2131536322 @default.
- W3089188356 cites W2132358997 @default.
- W3089188356 cites W2134241692 @default.
- W3089188356 cites W2138411980 @default.
- W3089188356 cites W2143728413 @default.
- W3089188356 cites W2147790901 @default.
- W3089188356 cites W2149515881 @default.
- W3089188356 cites W2151701113 @default.
- W3089188356 cites W2153075279 @default.
- W3089188356 cites W2153081066 @default.
- W3089188356 cites W2157305411 @default.
- W3089188356 cites W2160209604 @default.
- W3089188356 cites W2161645441 @default.
- W3089188356 cites W2165356529 @default.
- W3089188356 cites W2168526937 @default.
- W3089188356 cites W2170416289 @default.
- W3089188356 cites W2273797486 @default.
- W3089188356 cites W2297217814 @default.
- W3089188356 cites W2341244791 @default.
- W3089188356 cites W2344543878 @default.
- W3089188356 cites W2502597094 @default.
- W3089188356 cites W2528626298 @default.
- W3089188356 cites W2559267012 @default.
- W3089188356 cites W2599613070 @default.
- W3089188356 cites W2623246480 @default.
- W3089188356 cites W2627092521 @default.
- W3089188356 cites W2758183934 @default.
- W3089188356 cites W2762689525 @default.
- W3089188356 cites W2774551105 @default.
- W3089188356 cites W2780036753 @default.
- W3089188356 cites W2781286734 @default.
- W3089188356 cites W2887429059 @default.
- W3089188356 cites W2914171609 @default.
- W3089188356 cites W2917520831 @default.
- W3089188356 cites W2953331945 @default.
- W3089188356 cites W2954124338 @default.
- W3089188356 cites W3010829439 @default.
- W3089188356 cites W3033719616 @default.
- W3089188356 cites W3037819756 @default.
- W3089188356 cites W4210956151 @default.
- W3089188356 doi "https://doi.org/10.3390/nu12102932" @default.
- W3089188356 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7601677" @default.
- W3089188356 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32987923" @default.
- W3089188356 hasPublicationYear "2020" @default.
- W3089188356 type Work @default.