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• W3089188730 endingPage "e0239157" @default.
• W3089188730 startingPage "e0239157" @default.
• W3089188730 abstract "CD4dimCD8bright T cells, a genuine population of CD8+ T cells, are highly activated and cytolytic. Recently, the low affinity IgG Fc fragment receptor CD32a was described as marker of HIV latency while others reported that CD32a is associated with T cell activation. Given that we have previously established that CD4dimCD8bright T cells are highly activated, mediate anti-HIV responses, and are infected by HIV, we assessed here CD32 expression on CD4dimCD8bright T cells in context of HIV. CD32 frequency on peripheral CD4dimCD8bright and CD4+ T cells was determined by flow cytometry among HIV negative and HIV positive patients. We report that among HIV- individuals, mean CD32 percent expression was 60% on CD4dimCD8bright T cells and 17% on CD4+ T cells (p<0.01). Among HIV+ patients, mean CD32 percent expression was 54% on CD4dimCD8bright T cells and 12% on CD4+ T cells (p<0.001). CD32 expression on CD4dimCD8bright T cells did not correlate with CD4 count and viral load and was not different by HIV serostatus. CD32 was also higher on other double positive T cell populations in both HIV negative and HIV positive donors in comparison to their single positive T cell counterpart. Together, these studies indicate that CD32 is enriched on double positive T cells regardless of HIV serostatus. The functional role of CD32 on these double positive T cells remains to be elucidated." @default.
• W3089188730 created "2020-10-01" @default.
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• W3089188730 date "2020-09-22" @default.
• W3089188730 modified "2023-10-09" @default.
• W3089188730 title "CD32 is enriched on CD4dimCD8bright T cells" @default.
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• W3089188730 doi "https://doi.org/10.1371/journal.pone.0239157" @default.
• W3089188730 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7508398" @default.
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• W3089188730 hasPublicationYear "2020" @default.
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