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- W3089190851 abstract "The present investigation was aimed to study the anti-diabetic and hypolipidemic potential of Cinnamon cassia (Lauraceae family) bark in streptozotocin (STZ)-induced diabetic rats. The preliminary phytochemical analysis (hexane, petroleum ether, chloroform, ethanol, methanol, and aqueous extracts), GC-MS analysis (ethanol), in vitro (aqueous, ethanol and methanol), in vivo (ethanol) and in silico anti-diabetic activity with hypolipidemic effect of C. cassia bark was analysed. The ethanolic extract of the C. cassia bark has a fine inhibitory activity than the aqueous and methanolic extract. Out of 20 different compounds identified, seven compounds were biologically active, and 9-octadecenoic acid has highly interacted with PPARα/γ in docking studies. The levels of diabetic markers, enzymes, and lipid profiles were altered in STZ-induced rats, but after the treatment of C. cassia, the levels were returned to the normal. The study may prove the ethanolic extract of C. cassia has a powerful anti-diabetic and anti-hyperlipidemic activity." @default.
- W3089190851 created "2020-10-01" @default.
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- W3089190851 date "2020-09-28" @default.
- W3089190851 modified "2023-09-25" @default.
- W3089190851 title "Anti-diabetic and hypolipidemic effects of <i>Cinnamon cassia</i> bark extracts: an <i>in vitro</i>, <i>in vivo</i>, and <i>in silico</i> approach" @default.
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- W3089190851 doi "https://doi.org/10.1080/13813455.2020.1822415" @default.
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