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- W3089198112 endingPage "104317" @default.
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- W3089198112 abstract "Abstract Nine new (1–9) and four known (10–13) [13]cytochalasins, along with three known 24-oxa[14]cytochalasins (14–16), were isolated from the culture of Phoma multirostrata XJ-2-1, an endophytic fungus obtained from the fibrous root of Parasenecio albus. Their structures were elucidated by interpretation of the nuclear magnetic resonance (NMR) and high-resolution electrospray ionization mass spectroscopy (HRESIMS). The absolute configurations were assigned by single-crystal X-ray crystallography, modified Mosher′s method, and by analysis of their experimental electronic circular dichroism (ECD) spectra. Compound 6 could induce cell cycle arrest at G2-phase in CT26 and A549 cells, and displayed moderate cytotoxicity against CT26 and A549 cell lines with IC50 values of 6.03 and 5.04 μM, respectively. Co-treatment of 7–9, 13 and 16 with tumor necrosis factor related apoptosis inducing ligand (TRAIL) could significantly decrease the cell viability of A549, which revealed that cytochalasins could possibly be a new group of TRAIL sensitizers in lung cancer therapy." @default.
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- W3089198112 date "2020-11-01" @default.
- W3089198112 modified "2023-10-18" @default.
- W3089198112 title "Cytochalasins from an endophytic fungus Phoma multirostrata XJ-2-1 with cell cycle arrest and TRAIL-resistance-overcoming activities" @default.
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- W3089198112 doi "https://doi.org/10.1016/j.bioorg.2020.104317" @default.
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