Matches in SemOpenAlex for { <https://semopenalex.org/work/W3089199904> ?p ?o ?g. }
- W3089199904 abstract "This article reviews the scientific reasons that support the intriguing vision of pulmonary hypertension (PH) as a disease with a cancer-like nature and to understand whether this pointof view may have fruitful consequences for the overall management of PH. This review compares cancer and PH in view of Hanahan and Weinberg’s principles (i.e., hallmarks of cancer) with an emphasis on hyperproliferative, metabolic, and immune/inflammatory aspects of the disease.In addition, this review provides a perspective on the role of transcription factors and chromatin and epigenetic aberrations, besides genetics, as ‘‘common driving mechanisms’’ of PH hallmarks and the foreseeable use of transcription factor/epigenome targeting as multitarget approach against the hallmarks of PH. Thus, recognition of the widespread applicability and analogy of these concepts will increasingly affect the development of new means of PH treatment." @default.
- W3089199904 created "2020-10-01" @default.
- W3089199904 creator A5016511599 @default.
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- W3089199904 creator A5090020095 @default.
- W3089199904 date "2020-09-25" @default.
- W3089199904 modified "2023-09-23" @default.
- W3089199904 title "Cancer and pulmonary hypertension: Learning lessons and real-life interplay" @default.
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