FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3089203921> ?p ?o ?g. }

• W3089203921 endingPage "489" @default.
• W3089203921 startingPage "465" @default.
• W3089203921 abstract "Aspirin reduces colorectal cancer (CRC) incidence and mortality. Understanding the biology responsible for this protective effect is key to developing biomarker-led approaches for rational clinical use. Wnt signaling drives CRC development from initiation to progression through regulation of epithelial-mesenchymal transition (EMT) and cancer stem cell populations. Here, we investigated whether aspirin can rescue these proinvasive phenotypes associated with CRC progression in Wnt-driven human and mouse intestinal organoids.We evaluated aspirin-mediated effects on phenotype and stem cell markers in intestinal organoids derived from mouse (ApcMin/+ and Apcflox/flox) and human familial adenomatous polyposis patients. CRC cell lines (HCT116 and Colo205) were used to study effects on motility, invasion, Wnt signaling, and EMT.Aspirin rescues the Wnt-driven cystic organoid phenotype by promoting budding in mouse and human Apc deficient organoids, which is paralleled by decreased stem cell marker expression. Aspirin-mediated Wnt inhibition in ApcMin/+ mice is associated with EMT inhibition and decreased cell migration, invasion, and motility in CRC cell lines. Chemical Wnt activation induces EMT and stem-like alterations in CRC cells, which are rescued by aspirin. Aspirin increases expression of the Wnt antagonist Dickkopf-1 in CRC cells and organoids derived from familial adenomatous polyposis patients, which contributes to EMT and cancer stem cell inhibition.We provide evidence of phenotypic biomarkers of response to aspirin with an increased epithelial and reduced stem-like state mediated by an increase in Dickkopf-1. This highlights a novel mechanism of aspirin-mediated Wnt inhibition and potential phenotypic and molecular biomarkers for trials." @default.
• W3089203921 created "2020-10-01" @default.
• W3089203921 creator A5000523003 @default.
• W3089203921 creator A5004655780 @default.
• W3089203921 creator A5005186043 @default.
• W3089203921 creator A5007530177 @default.
• W3089203921 creator A5010158929 @default.
• W3089203921 creator A5015124075 @default.
• W3089203921 creator A5019378167 @default.
• W3089203921 creator A5029428533 @default.
• W3089203921 creator A5037607675 @default.
• W3089203921 creator A5040957546 @default.
• W3089203921 creator A5041042009 @default.
• W3089203921 creator A5042410875 @default.
• W3089203921 creator A5043960284 @default.
• W3089203921 creator A5051562548 @default.
• W3089203921 creator A5059106596 @default.
• W3089203921 creator A5061494035 @default.
• W3089203921 date "2021-01-01" @default.
• W3089203921 modified "2023-10-15" @default.
• W3089203921 title "Aspirin Rescues Wnt-Driven Stem-like Phenotype in Human Intestinal Organoids and Increases the Wnt Antagonist Dickkopf-1" @default.
• W3089203921 cites W128983294 @default.
• W3089203921 cites W1655178001 @default.
• W3089203921 cites W1955712601 @default.
• W3089203921 cites W1965157206 @default.
• W3089203921 cites W1967073403 @default.
• W3089203921 cites W1980779035 @default.
• W3089203921 cites W1982603620 @default.
• W3089203921 cites W1984110531 @default.
• W3089203921 cites W1986511854 @default.
• W3089203921 cites W1990339803 @default.
• W3089203921 cites W1993677820 @default.
• W3089203921 cites W1997114875 @default.
• W3089203921 cites W1997452920 @default.
• W3089203921 cites W2002513358 @default.
• W3089203921 cites W2006419043 @default.
• W3089203921 cites W2009134460 @default.
• W3089203921 cites W2014691022 @default.
• W3089203921 cites W2021370278 @default.
• W3089203921 cites W2035732765 @default.
• W3089203921 cites W2038714514 @default.
• W3089203921 cites W2040630905 @default.
• W3089203921 cites W2043854938 @default.
• W3089203921 cites W2047283612 @default.
• W3089203921 cites W2055808176 @default.
• W3089203921 cites W2057199920 @default.
• W3089203921 cites W2086627696 @default.
• W3089203921 cites W2098251879 @default.
• W3089203921 cites W2100794488 @default.
• W3089203921 cites W2103955948 @default.
• W3089203921 cites W2109832697 @default.
• W3089203921 cites W2113724152 @default.
• W3089203921 cites W2117765445 @default.
• W3089203921 cites W2123059506 @default.
• W3089203921 cites W2154589460 @default.
• W3089203921 cites W2155507705 @default.
• W3089203921 cites W2162756888 @default.
• W3089203921 cites W2164618834 @default.
• W3089203921 cites W2166330632 @default.
• W3089203921 cites W2258083311 @default.
• W3089203921 cites W2262329766 @default.
• W3089203921 cites W2268209490 @default.
• W3089203921 cites W2313789480 @default.
• W3089203921 cites W2321598543 @default.
• W3089203921 cites W2555771555 @default.
• W3089203921 cites W2566508441 @default.
• W3089203921 cites W2771961685 @default.
• W3089203921 cites W2782235189 @default.
• W3089203921 cites W2789752559 @default.
• W3089203921 cites W2800767804 @default.
• W3089203921 cites W2803549477 @default.
• W3089203921 cites W2808674655 @default.
• W3089203921 cites W2895775371 @default.
• W3089203921 cites W2917791553 @default.
• W3089203921 cites W2952481429 @default.
• W3089203921 cites W2976380466 @default.
• W3089203921 cites W2987842064 @default.
• W3089203921 cites W3004712367 @default.
• W3089203921 cites W3012977754 @default.
• W3089203921 cites W3014561685 @default.
• W3089203921 cites W3014713533 @default.
• W3089203921 cites W3020093160 @default.
• W3089203921 cites W3028106501 @default.
• W3089203921 cites W4235356884 @default.
• W3089203921 doi "https://doi.org/10.1016/j.jcmgh.2020.09.010" @default.
• W3089203921 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7797380" @default.
• W3089203921 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32971322" @default.
• W3089203921 hasPublicationYear "2021" @default.
• W3089203921 type Work @default.
• W3089203921 sameAs 3089203921 @default.
• W3089203921 citedByCount "13" @default.
• W3089203921 countsByYear W30892039212020 @default.
• W3089203921 countsByYear W30892039212021 @default.
• W3089203921 countsByYear W30892039212022 @default.
• W3089203921 countsByYear W30892039212023 @default.
• W3089203921 crossrefType "journal-article" @default.
• W3089203921 hasAuthorship W3089203921A5000523003 @default.
• W3089203921 hasAuthorship W3089203921A5004655780 @default.

• next