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• W3089210822 abstract "The treatment of transplant-eligible multiple myeloma patients in Italy consists in an induction phase based on bortezomib plus thalidomide plus dexamethasone (VTd), followed by a single or tandem autologous stem cell transplantation (ASCT), followed by lenalidomide maintenance. This approach offers an overall response rate of 93% and a CR rate of 58% with acceptable toxicity. Lenalidomide maintenance adds a significant increase in disease control, with a progression free survival after ASCT of 53 months, and an overall survival of 86 months. Second primary malignancies represent the most concerning toxicity of lenalidomide maintenance with a 6.9% incidence. However, the benefit in terms of increased myeloma control largely outweigh this complication. The incorporation of daratumumab in this treatment schema will further improve these clinical results." @default.
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• W3089210822 date "2020-09-21" @default.
• W3089210822 modified "2023-10-18" @default.
• W3089210822 title "How I manage frontline transplant-eligible multiple myeloma in Italy" @default.
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• W3089210822 doi "https://doi.org/10.4081/hr.2020.8954" @default.
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