Matches in SemOpenAlex for { <https://semopenalex.org/work/W3089211314> ?p ?o ?g. }
- W3089211314 endingPage "2518" @default.
- W3089211314 startingPage "2511" @default.
- W3089211314 abstract "Abstract Microglia are phagocytic cells involved in homeostasis of the brain and are key players in the pathogenesis of multiple sclerosis (MS). A hallmark of MS diagnosis is the presence of IgG Abs, which appear as oligoclonal bands in the cerebrospinal fluid. In this study, we demonstrate that myelin obtained post mortem from 8 out of 11 MS brain donors is bound by IgG Abs. Importantly, we show that IgG immune complexes strongly potentiate activation of primary human microglia by breaking their tolerance for microbial stimuli, such as LPS and Poly I:C, resulting in increased production of key proinflammatory cytokines, such as TNF and IL-1β. We identified FcγRI and FcγRIIa as the two main responsible IgG receptors for the breaking of immune tolerance of microglia. Combined, these data indicate that IgG immune complexes potentiate inflammation by human microglia, which may play an important role in MS-associated inflammation and the formation of demyelinating lesions." @default.
- W3089211314 created "2020-10-01" @default.
- W3089211314 creator A5003382210 @default.
- W3089211314 creator A5005739479 @default.
- W3089211314 creator A5026990397 @default.
- W3089211314 creator A5060136306 @default.
- W3089211314 creator A5088279602 @default.
- W3089211314 date "2020-11-01" @default.
- W3089211314 modified "2023-10-10" @default.
- W3089211314 title "IgG Immune Complexes Break Immune Tolerance of Human Microglia" @default.
- W3089211314 cites W1994439483 @default.
- W3089211314 cites W2006522040 @default.
- W3089211314 cites W2009103286 @default.
- W3089211314 cites W2025844396 @default.
- W3089211314 cites W2036261151 @default.
- W3089211314 cites W2036924619 @default.
- W3089211314 cites W2057033229 @default.
- W3089211314 cites W2058094904 @default.
- W3089211314 cites W2075901113 @default.
- W3089211314 cites W2089967493 @default.
- W3089211314 cites W2090777067 @default.
- W3089211314 cites W2092927038 @default.
- W3089211314 cites W2109315419 @default.
- W3089211314 cites W2114061884 @default.
- W3089211314 cites W2118282588 @default.
- W3089211314 cites W2123516767 @default.
- W3089211314 cites W2128032070 @default.
- W3089211314 cites W2135109315 @default.
- W3089211314 cites W2147062889 @default.
- W3089211314 cites W2152571679 @default.
- W3089211314 cites W2160688467 @default.
- W3089211314 cites W2165547142 @default.
- W3089211314 cites W2170706621 @default.
- W3089211314 cites W2588541474 @default.
- W3089211314 cites W2612475282 @default.
- W3089211314 cites W2626252716 @default.
- W3089211314 cites W2769071992 @default.
- W3089211314 cites W2784314693 @default.
- W3089211314 cites W2788632940 @default.
- W3089211314 cites W2789451443 @default.
- W3089211314 cites W2805197831 @default.
- W3089211314 cites W2890087248 @default.
- W3089211314 cites W2909270098 @default.
- W3089211314 cites W2909562696 @default.
- W3089211314 cites W2921234203 @default.
- W3089211314 cites W2939607606 @default.
- W3089211314 cites W2976957583 @default.
- W3089211314 cites W2978969137 @default.
- W3089211314 doi "https://doi.org/10.4049/jimmunol.2000130" @default.
- W3089211314 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32967931" @default.
- W3089211314 hasPublicationYear "2020" @default.
- W3089211314 type Work @default.
- W3089211314 sameAs 3089211314 @default.
- W3089211314 citedByCount "15" @default.
- W3089211314 countsByYear W30892113142020 @default.
- W3089211314 countsByYear W30892113142021 @default.
- W3089211314 countsByYear W30892113142022 @default.
- W3089211314 countsByYear W30892113142023 @default.
- W3089211314 crossrefType "journal-article" @default.
- W3089211314 hasAuthorship W3089211314A5003382210 @default.
- W3089211314 hasAuthorship W3089211314A5005739479 @default.
- W3089211314 hasAuthorship W3089211314A5026990397 @default.
- W3089211314 hasAuthorship W3089211314A5060136306 @default.
- W3089211314 hasAuthorship W3089211314A5088279602 @default.
- W3089211314 hasBestOaLocation W30892113141 @default.
- W3089211314 hasConcept C164027704 @default.
- W3089211314 hasConcept C203014093 @default.
- W3089211314 hasConcept C2776914184 @default.
- W3089211314 hasConcept C2779830541 @default.
- W3089211314 hasConcept C2780640218 @default.
- W3089211314 hasConcept C2780942790 @default.
- W3089211314 hasConcept C71924100 @default.
- W3089211314 hasConcept C8891405 @default.
- W3089211314 hasConceptScore W3089211314C164027704 @default.
- W3089211314 hasConceptScore W3089211314C203014093 @default.
- W3089211314 hasConceptScore W3089211314C2776914184 @default.
- W3089211314 hasConceptScore W3089211314C2779830541 @default.
- W3089211314 hasConceptScore W3089211314C2780640218 @default.
- W3089211314 hasConceptScore W3089211314C2780942790 @default.
- W3089211314 hasConceptScore W3089211314C71924100 @default.
- W3089211314 hasConceptScore W3089211314C8891405 @default.
- W3089211314 hasFunder F4320321646 @default.
- W3089211314 hasIssue "9" @default.
- W3089211314 hasLocation W30892113141 @default.
- W3089211314 hasOpenAccess W3089211314 @default.
- W3089211314 hasPrimaryLocation W30892113141 @default.
- W3089211314 hasRelatedWork W2165578318 @default.
- W3089211314 hasRelatedWork W2186316345 @default.
- W3089211314 hasRelatedWork W2313033156 @default.
- W3089211314 hasRelatedWork W2353163157 @default.
- W3089211314 hasRelatedWork W2368039737 @default.
- W3089211314 hasRelatedWork W2617222556 @default.
- W3089211314 hasRelatedWork W2765411704 @default.
- W3089211314 hasRelatedWork W4214846118 @default.
- W3089211314 hasRelatedWork W4309706999 @default.
- W3089211314 hasRelatedWork W4376609483 @default.
- W3089211314 hasVolume "205" @default.
- W3089211314 isParatext "false" @default.