FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3089224743> ?p ?o ?g. }

• W3089224743 endingPage "2585" @default.
• W3089224743 startingPage "2573" @default.
• W3089224743 abstract "Abstract Background Carbapenemase-producing Klebsiella pneumoniae (CP-Kp) poses distinct clinical challenges due to extensively drug resistant (XDR) phenotype, and sequence type (ST) 11 is the most dominant bla KPC-2 -bearing CP-Kp clone in China. The purpose of this current retrospective study was to explore the genetic factors associated with the success of XDR CP-Kp ST11 strains circulated in the intensive care unit (ICU) of a Chinese tertiary hospital. Methods Six ST11 XDR CP-Kp strains were identified between May and December 2014 and validated by minimum inhibitory concentration examination, polymerase chain reaction, and pyrosequencing. The six ST11 XDR CP-Kp, as well as three multi-drug resistant (MDR) and four susceptible strains, were sequenced using single-molecule real-time method. Comprehensively structural and functional analysis based on comparative genomics was performed to identify genomic characteristics of the XDR ST11 CP-Kp strains. Results We found that ST11 XDR bla KPC-2 -bearing CP-Kp strains isolated from inpatients spread in the ICU of the hospital. Functionally, genes associated with information storage and processing of the ST11 XDR CP-Kp strains were more abundant than those of MDR and susceptible strains, especially genes correlative with mobile genetic elements (MGEs) such as transposons and prophages. Structurally, eleven large-scale genetic regions taken for the unique genome in these ST11 XDR CP-Kp strains were identified as MGEs including transposons, integrons, prophages, genomic islands, and integrative and conjugative elements. Three of them were located on plasmids and eight on chromosomes; five of them were with antimicrobial resistance genes and eight with adaptation associated genes. Notably, a new bla KPC-2 -bearing ΔΔTn1721- bla KPC-2 transposon, probably transposed and truncated from ΔTn1721- bla KPC-2 by IS903D and ISKpn8, was identified in all six ST11 XDR CP-Kp strains. Conclusion Our findings suggested that together with clonal spread, MGEs identified uniquely in the ST11 XDR CP-Kp strains might contribute to their formidable adaptability, which facilitated their widespread dissemination in hospital." @default.
• W3089224743 created "2020-10-01" @default.
• W3089224743 creator A5001855236 @default.
• W3089224743 creator A5010248726 @default.
• W3089224743 creator A5022340603 @default.
• W3089224743 creator A5030531770 @default.
• W3089224743 creator A5058949420 @default.
• W3089224743 creator A5064582358 @default.
• W3089224743 creator A5065361552 @default.
• W3089224743 creator A5067111953 @default.
• W3089224743 creator A5072242569 @default.
• W3089224743 creator A5080510405 @default.
• W3089224743 date "2020-09-24" @default.
• W3089224743 modified "2023-10-16" @default.
• W3089224743 title "Genetic factors related to the widespread dissemination of ST11 extensively drug-resistant carbapenemase-producing Klebsiella pneumoniae strains within hospital" @default.
• W3089224743 cites W1830119115 @default.
• W3089224743 cites W1900868038 @default.
• W3089224743 cites W1966218520 @default.
• W3089224743 cites W1976414566 @default.
• W3089224743 cites W1985270197 @default.
• W3089224743 cites W1985981101 @default.
• W3089224743 cites W1997509815 @default.
• W3089224743 cites W2027831845 @default.
• W3089224743 cites W2031611770 @default.
• W3089224743 cites W2033506862 @default.
• W3089224743 cites W2045068581 @default.
• W3089224743 cites W2055615325 @default.
• W3089224743 cites W2061729558 @default.
• W3089224743 cites W2063669406 @default.
• W3089224743 cites W2078043965 @default.
• W3089224743 cites W2088527369 @default.
• W3089224743 cites W2091030812 @default.
• W3089224743 cites W2097910397 @default.
• W3089224743 cites W2103956044 @default.
• W3089224743 cites W2104039523 @default.
• W3089224743 cites W2105924489 @default.
• W3089224743 cites W2108034897 @default.
• W3089224743 cites W2112821341 @default.
• W3089224743 cites W2114853012 @default.
• W3089224743 cites W2116617401 @default.
• W3089224743 cites W2120080883 @default.
• W3089224743 cites W2120326663 @default.
• W3089224743 cites W2129978006 @default.
• W3089224743 cites W2142343447 @default.
• W3089224743 cites W2144548073 @default.
• W3089224743 cites W2145111808 @default.
• W3089224743 cites W2150987636 @default.
• W3089224743 cites W2156125289 @default.
• W3089224743 cites W2156301231 @default.
• W3089224743 cites W2172153318 @default.
• W3089224743 cites W2216357618 @default.
• W3089224743 cites W2217152516 @default.
• W3089224743 cites W2219249837 @default.
• W3089224743 cites W2508745223 @default.
• W3089224743 cites W2517396633 @default.
• W3089224743 cites W2544493586 @default.
• W3089224743 cites W2546689803 @default.
• W3089224743 cites W2586503825 @default.
• W3089224743 cites W2615583214 @default.
• W3089224743 cites W2621213453 @default.
• W3089224743 cites W2728170331 @default.
• W3089224743 cites W2743038938 @default.
• W3089224743 cites W2749993286 @default.
• W3089224743 cites W2753207233 @default.
• W3089224743 cites W2782108004 @default.
• W3089224743 cites W2806714940 @default.
• W3089224743 cites W2807056642 @default.
• W3089224743 cites W2807702980 @default.
• W3089224743 cites W2810366941 @default.
• W3089224743 cites W2811399003 @default.
• W3089224743 cites W2883544378 @default.
• W3089224743 cites W2891956809 @default.
• W3089224743 cites W2896165043 @default.
• W3089224743 cites W2901874874 @default.
• W3089224743 cites W2905572899 @default.
• W3089224743 cites W2912386258 @default.
• W3089224743 cites W2922037673 @default.
• W3089224743 cites W2958211769 @default.
• W3089224743 cites W2965393343 @default.
• W3089224743 cites W2973643612 @default.
• W3089224743 cites W2976990720 @default.
• W3089224743 cites W2979766665 @default.
• W3089224743 cites W2982583142 @default.
• W3089224743 cites W2987898767 @default.
• W3089224743 cites W2996333711 @default.
• W3089224743 cites W2998831465 @default.
• W3089224743 cites W3011796094 @default.
• W3089224743 cites W3025195689 @default.
• W3089224743 doi "https://doi.org/10.1097/cm9.0000000000001101" @default.
• W3089224743 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7722564" @default.
• W3089224743 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32969865" @default.
• W3089224743 hasPublicationYear "2020" @default.
• W3089224743 type Work @default.
• W3089224743 sameAs 3089224743 @default.
• W3089224743 citedByCount "4" @default.
• W3089224743 countsByYear W30892247432021 @default.
• W3089224743 countsByYear W30892247432022 @default.
• W3089224743 countsByYear W30892247432023 @default.

• next