Matches in SemOpenAlex for { <https://semopenalex.org/work/W3089237778> ?p ?o ?g. }
Showing items 1 to 85 of
85
with 100 items per page.
- W3089237778 abstract "Abstract All living organisms contain a unique class of molecular chaperones called 60 kDa heat shock proteins (HSP60 – also known as GroEL in bacteria). While some organisms contain more than one HSP60 or GroEL isoform, at least one isoform has always proven to be essential. Because of this, we have been investigating targeting HSP60 and GroEL chaperonin systems as an antibiotic strategy. Our initial studies focused on applying this antibiotic strategy for treating African sleeping sickness (caused by Trypanosoma brucei parasites) and drug-resistant bacterial infections (in particular Methicillin-resistant Staphylococcus aureus – MRSA). Intriguingly, during our studies we found that three known antibiotics – suramin, closantel, and rafoxanide – were potent inhibitors of bacterial GroEL and human HSP60 chaperonin systems. These findings prompted us to explore what other approved drugs, natural products, and known bioactive molecules might also inhibit HSP60 and GroEL chaperonin systems. Initial high-throughput screening of 3680 approved drugs, natural products, and known bioactives identified 161 hit inhibitors of the Escherichia coli GroEL chaperonin system (4.3% hit rate). From a purchased subset of 60 hits, 29 compounds (48%) re-confirmed as selective GroEL inhibitors in our assays, all of which were nearly equipotent against human HSP60. These findings illuminate the notion that targeting chaperonin systems might be a more common occurrence than we previously appreciated. Future studies are needed to determine if the in vivo modes of action of these approved drugs, natural products, and known bioactive molecules are related to GroEL and HSP60 inhibition." @default.
- W3089237778 created "2020-10-01" @default.
- W3089237778 creator A5002042871 @default.
- W3089237778 creator A5009005886 @default.
- W3089237778 creator A5020704398 @default.
- W3089237778 creator A5024562621 @default.
- W3089237778 creator A5036871501 @default.
- W3089237778 creator A5038951690 @default.
- W3089237778 creator A5041727371 @default.
- W3089237778 creator A5057562012 @default.
- W3089237778 creator A5074925440 @default.
- W3089237778 creator A5083715536 @default.
- W3089237778 creator A5084165762 @default.
- W3089237778 date "2019-05-01" @default.
- W3089237778 modified "2023-09-26" @default.
- W3089237778 title "HSP60/10 chaperonin systems are inhibited by a variety of approved drugs, natural products, and known bioactive molecules" @default.
- W3089237778 hasPublicationYear "2019" @default.
- W3089237778 type Work @default.
- W3089237778 sameAs 3089237778 @default.
- W3089237778 citedByCount "0" @default.
- W3089237778 crossrefType "journal-article" @default.
- W3089237778 hasAuthorship W3089237778A5002042871 @default.
- W3089237778 hasAuthorship W3089237778A5009005886 @default.
- W3089237778 hasAuthorship W3089237778A5020704398 @default.
- W3089237778 hasAuthorship W3089237778A5024562621 @default.
- W3089237778 hasAuthorship W3089237778A5036871501 @default.
- W3089237778 hasAuthorship W3089237778A5038951690 @default.
- W3089237778 hasAuthorship W3089237778A5041727371 @default.
- W3089237778 hasAuthorship W3089237778A5057562012 @default.
- W3089237778 hasAuthorship W3089237778A5074925440 @default.
- W3089237778 hasAuthorship W3089237778A5083715536 @default.
- W3089237778 hasAuthorship W3089237778A5084165762 @default.
- W3089237778 hasConcept C104317684 @default.
- W3089237778 hasConcept C146621620 @default.
- W3089237778 hasConcept C159047783 @default.
- W3089237778 hasConcept C204328495 @default.
- W3089237778 hasConcept C205260736 @default.
- W3089237778 hasConcept C46522908 @default.
- W3089237778 hasConcept C547475151 @default.
- W3089237778 hasConcept C55493867 @default.
- W3089237778 hasConcept C68991219 @default.
- W3089237778 hasConcept C85755625 @default.
- W3089237778 hasConcept C86803240 @default.
- W3089237778 hasConcept C87190427 @default.
- W3089237778 hasConcept C89423630 @default.
- W3089237778 hasConceptScore W3089237778C104317684 @default.
- W3089237778 hasConceptScore W3089237778C146621620 @default.
- W3089237778 hasConceptScore W3089237778C159047783 @default.
- W3089237778 hasConceptScore W3089237778C204328495 @default.
- W3089237778 hasConceptScore W3089237778C205260736 @default.
- W3089237778 hasConceptScore W3089237778C46522908 @default.
- W3089237778 hasConceptScore W3089237778C547475151 @default.
- W3089237778 hasConceptScore W3089237778C55493867 @default.
- W3089237778 hasConceptScore W3089237778C68991219 @default.
- W3089237778 hasConceptScore W3089237778C85755625 @default.
- W3089237778 hasConceptScore W3089237778C86803240 @default.
- W3089237778 hasConceptScore W3089237778C87190427 @default.
- W3089237778 hasConceptScore W3089237778C89423630 @default.
- W3089237778 hasLocation W30892377781 @default.
- W3089237778 hasOpenAccess W3089237778 @default.
- W3089237778 hasPrimaryLocation W30892377781 @default.
- W3089237778 hasRelatedWork W1509809597 @default.
- W3089237778 hasRelatedWork W1513237427 @default.
- W3089237778 hasRelatedWork W2007340510 @default.
- W3089237778 hasRelatedWork W2010424789 @default.
- W3089237778 hasRelatedWork W2034872394 @default.
- W3089237778 hasRelatedWork W2077236497 @default.
- W3089237778 hasRelatedWork W2095718201 @default.
- W3089237778 hasRelatedWork W2146681881 @default.
- W3089237778 hasRelatedWork W2148950867 @default.
- W3089237778 hasRelatedWork W2152444450 @default.
- W3089237778 hasRelatedWork W2157355956 @default.
- W3089237778 hasRelatedWork W2331786242 @default.
- W3089237778 hasRelatedWork W2347177626 @default.
- W3089237778 hasRelatedWork W2799662254 @default.
- W3089237778 hasRelatedWork W2801176478 @default.
- W3089237778 hasRelatedWork W2918666868 @default.
- W3089237778 hasRelatedWork W2985935591 @default.
- W3089237778 hasRelatedWork W3007751869 @default.
- W3089237778 hasRelatedWork W779778759 @default.
- W3089237778 hasRelatedWork W2246793940 @default.
- W3089237778 isParatext "false" @default.
- W3089237778 isRetracted "false" @default.
- W3089237778 magId "3089237778" @default.
- W3089237778 workType "article" @default.