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- W3089240640 abstract "Abstract Metastasis remains the leading cause of cancer-associated mortality, and a detailed understanding of the metastatic process could suggest new therapeutic avenues. However, how metastatic phenotypes arise at the genomic level has remained a major open question in cancer biology. Comparative genetic studies of primary and metastatic cancers have revealed a complex picture of metastatic evolution with diverse temporal patterns and trajectories to dissemination. Whole-genome amplification is associated with metastatic cancer clones, but no metastasis-exclusive driver mutations have emerged. Instead, genetically activated oncogenic pathways that drive tumour initiation and early progression acquire metastatic traits by co-opting physiological programmes from stem cell, developmental and regenerative pathways. The functional consequences of oncogenic driver mutations therefore change via epigenetic mechanisms to promote metastasis. Increasing evidence is starting to uncover the molecular mechanisms that determine how specific oncogenic drivers interact with various physiological programmes, and what triggers their activation in support of metastasis. Detailed insight into the mechanisms that control metastasis is likely to reveal novel opportunities for intervention at different stages of metastatic progression." @default.
- W3089240640 created "2020-10-01" @default.
- W3089240640 creator A5026788125 @default.
- W3089240640 creator A5066441233 @default.
- W3089240640 creator A5072503541 @default.
- W3089240640 creator A5089999973 @default.
- W3089240640 date "2020-11-04" @default.
- W3089240640 modified "2023-10-06" @default.
- W3089240640 title "Genomic control of metastasis" @default.
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