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- W3089245934 abstract "Abstract Migrating cells move across diverse assemblies of extracellular matrix (ECM) that can be separated by micron-scale gaps. For membranes to protrude and reattach across a gap, actin filaments, which are relatively weak as single filaments, must polymerize outward from adhesion sites to push membranes towards distant sites of new adhesion. Here, using micropatterned ECMs, we identify T-Plastin, one of the most ancient actin bundling proteins, as an actin stabilizer that promotes membrane protrusions and enables bridging of ECM gaps. We show that T-Plastin widens and lengthens protrusions and is specifically enriched in active protrusions where F-actin is devoid of non-muscle myosin II activity. Together, our study uncovers critical roles of the actin bundler T-Plastin to promote protrusions and migration when adhesion is spatially-gapped." @default.
- W3089245934 created "2020-10-01" @default.
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- W3089245934 date "2020-09-23" @default.
- W3089245934 modified "2023-10-14" @default.
- W3089245934 title "T-Plastin reinforces membrane protrusions to bridge matrix gaps during cell migration" @default.
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- W3089245934 doi "https://doi.org/10.1038/s41467-020-18586-3" @default.
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