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- W3089260492 abstract "Rheumatoid arthritis (RA) is a chronic inflammatory syndrome designated by synovial joint inflammation leading to cartilage degradation and bone damage as well as progressive disability. Synovial inflammation is promoted through the infiltration of mononuclear immune cells, dominated by CD4+ T cells, macrophages and dendritic cells (DCs), together with fibroblast-like synoviocytes (FLS), into the synovial compartment. Berberine is a bioactive isoquinoline alkaloid compound showing various pharmacological properties that are mainly attributed to immunomodulatory and anti-inflammatory effects. Several lines of experimental study have recently investigated the therapeutic potential of berberine and its underlying mechanisms in treating RA condition. The present review aimed to clarify determinant cellular and molecular targets of berberine in RA and found that berberine through modulating several signalling pathways involved in the joint inflammation, including PI3K/Akt, Wnt1/β-catenin, AMPK/lipogenesis and LPA/LPA1/ERK/p38 MAPK can inhibit inflammatory proliferation of FLS cells, suppress DC activation and modulate Th17/Treg balance and thus prevent cartilage and bone destruction. Importantly, these molecular targets may explore new therapeutic targets for RA treatment." @default.
- W3089260492 created "2020-10-01" @default.
- W3089260492 creator A5002669249 @default.
- W3089260492 creator A5006330413 @default.
- W3089260492 creator A5013276658 @default.
- W3089260492 creator A5059955076 @default.
- W3089260492 creator A5061407463 @default.
- W3089260492 date "2020-09-23" @default.
- W3089260492 modified "2023-10-13" @default.
- W3089260492 title "Immunomodulatory effects of berberine on the inflamed joint reveal new therapeutic targets for rheumatoid arthritis management" @default.
- W3089260492 cites W1494759368 @default.
- W3089260492 cites W1551485069 @default.
- W3089260492 cites W1570290817 @default.
- W3089260492 cites W1603866561 @default.
- W3089260492 cites W1735223593 @default.
- W3089260492 cites W1859037964 @default.
- W3089260492 cites W1899250089 @default.
- W3089260492 cites W1926625412 @default.
- W3089260492 cites W1977544181 @default.
- W3089260492 cites W1979239025 @default.
- W3089260492 cites W1980062259 @default.
- W3089260492 cites W1985968831 @default.
- W3089260492 cites W1987032872 @default.
- W3089260492 cites W1997131908 @default.
- W3089260492 cites W1998263932 @default.
- W3089260492 cites W2000468514 @default.
- W3089260492 cites W2000539788 @default.
- W3089260492 cites W2006352454 @default.
- W3089260492 cites W2008179404 @default.
- W3089260492 cites W2016124686 @default.
- W3089260492 cites W2016950635 @default.
- W3089260492 cites W2017884068 @default.
- W3089260492 cites W2022720370 @default.
- W3089260492 cites W2028447671 @default.
- W3089260492 cites W2029043449 @default.
- W3089260492 cites W2032362610 @default.
- W3089260492 cites W2035636765 @default.
- W3089260492 cites W2035645353 @default.
- W3089260492 cites W2036561821 @default.
- W3089260492 cites W2036606290 @default.
- W3089260492 cites W2036615406 @default.
- W3089260492 cites W2037275677 @default.
- W3089260492 cites W2037882607 @default.
- W3089260492 cites W2044068623 @default.
- W3089260492 cites W2047677831 @default.
- W3089260492 cites W2051249644 @default.
- W3089260492 cites W2052770133 @default.
- W3089260492 cites W2060523664 @default.
- W3089260492 cites W2061687700 @default.
- W3089260492 cites W2076357723 @default.
- W3089260492 cites W2076681736 @default.
- W3089260492 cites W2076738925 @default.
- W3089260492 cites W2079183971 @default.
- W3089260492 cites W2079857881 @default.
- W3089260492 cites W2083299002 @default.
- W3089260492 cites W2084111853 @default.
- W3089260492 cites W2089162433 @default.
- W3089260492 cites W2092602103 @default.
- W3089260492 cites W2095512005 @default.
- W3089260492 cites W2097040991 @default.
- W3089260492 cites W2098443925 @default.
- W3089260492 cites W2101781154 @default.
- W3089260492 cites W2101884412 @default.
- W3089260492 cites W2121021320 @default.
- W3089260492 cites W2121477019 @default.
- W3089260492 cites W2129224427 @default.
- W3089260492 cites W2131439006 @default.
- W3089260492 cites W2132981126 @default.
- W3089260492 cites W2135851159 @default.
- W3089260492 cites W2136357996 @default.
- W3089260492 cites W2140016144 @default.
- W3089260492 cites W2141300701 @default.
- W3089260492 cites W2147579309 @default.
- W3089260492 cites W2148293348 @default.
- W3089260492 cites W2149146043 @default.
- W3089260492 cites W2153627006 @default.
- W3089260492 cites W2156267537 @default.
- W3089260492 cites W2157783220 @default.
- W3089260492 cites W2158353135 @default.
- W3089260492 cites W2159560982 @default.
- W3089260492 cites W2169364567 @default.
- W3089260492 cites W2171722021 @default.
- W3089260492 cites W2197147864 @default.
- W3089260492 cites W2295815669 @default.
- W3089260492 cites W2299840252 @default.
- W3089260492 cites W2302378943 @default.
- W3089260492 cites W2312928480 @default.
- W3089260492 cites W2340889176 @default.
- W3089260492 cites W2399064224 @default.
- W3089260492 cites W2415793789 @default.
- W3089260492 cites W2469986620 @default.
- W3089260492 cites W2520504342 @default.
- W3089260492 cites W2525906202 @default.
- W3089260492 cites W2565151406 @default.
- W3089260492 cites W2576602781 @default.
- W3089260492 cites W2586545208 @default.
- W3089260492 cites W2591619117 @default.
- W3089260492 cites W2618183351 @default.