Matches in SemOpenAlex for { <https://semopenalex.org/work/W3089285910> ?p ?o ?g. }
- W3089285910 endingPage "908" @default.
- W3089285910 startingPage "908" @default.
- W3089285910 abstract "Fentanyl is widely used for analgesia, sedation, and anesthesia both in adult and pediatric populations. Yet, only few pharmacokinetic studies of fentanyl in pediatrics exist as conducting clinical trials in this population is especially challenging. Physiologically-based pharmacokinetic (PBPK) modeling is a mechanistic approach to explore drug pharmacokinetics and allows extrapolation from adult to pediatric populations based on age-related physiological differences. The aim of this study was to develop a PBPK model of fentanyl and norfentanyl for both adult and pediatric populations. The adult PBPK model was established in PK-Sim® using data from 16 clinical studies and was scaled to several pediatric subpopulations. ~93% of the predicted AUClast values in adults and ~88% in pediatrics were within 2-fold of the corresponding value observed. The adult PBPK model predicted a fraction of fentanyl dose metabolized to norfentanyl of ~33% and a fraction excreted in urine of ~7%. In addition, the pediatric PBPK model was used to simulate differences in peak plasma concentrations after bolus injections and short infusions. The novel PBPK models could be helpful to further investigate fentanyl pharmacokinetics in both adult and pediatric populations." @default.
- W3089285910 created "2020-10-01" @default.
- W3089285910 creator A5023520269 @default.
- W3089285910 creator A5051567097 @default.
- W3089285910 creator A5058057231 @default.
- W3089285910 creator A5065833268 @default.
- W3089285910 creator A5075293871 @default.
- W3089285910 creator A5077331454 @default.
- W3089285910 creator A5080593565 @default.
- W3089285910 creator A5080845006 @default.
- W3089285910 date "2020-09-23" @default.
- W3089285910 modified "2023-10-10" @default.
- W3089285910 title "Physiologically-Based Pharmacokinetic (PBPK) Modeling Providing Insights into Fentanyl Pharmacokinetics in Adults and Pediatric Patients" @default.
- W3089285910 cites W1481128086 @default.
- W3089285910 cites W1884274622 @default.
- W3089285910 cites W1924556298 @default.
- W3089285910 cites W1964730967 @default.
- W3089285910 cites W1965684574 @default.
- W3089285910 cites W1967806735 @default.
- W3089285910 cites W1973043914 @default.
- W3089285910 cites W1976926513 @default.
- W3089285910 cites W1979930569 @default.
- W3089285910 cites W1982940569 @default.
- W3089285910 cites W1987638653 @default.
- W3089285910 cites W1996122919 @default.
- W3089285910 cites W2008196188 @default.
- W3089285910 cites W2012513302 @default.
- W3089285910 cites W2018432695 @default.
- W3089285910 cites W2018632954 @default.
- W3089285910 cites W2025621686 @default.
- W3089285910 cites W2026015795 @default.
- W3089285910 cites W2028165836 @default.
- W3089285910 cites W2028222258 @default.
- W3089285910 cites W2029695269 @default.
- W3089285910 cites W2031428717 @default.
- W3089285910 cites W2031941596 @default.
- W3089285910 cites W2034572193 @default.
- W3089285910 cites W2035900027 @default.
- W3089285910 cites W2043123177 @default.
- W3089285910 cites W2043450280 @default.
- W3089285910 cites W2052406081 @default.
- W3089285910 cites W2053482222 @default.
- W3089285910 cites W2058457951 @default.
- W3089285910 cites W2071127215 @default.
- W3089285910 cites W2074772662 @default.
- W3089285910 cites W2075131386 @default.
- W3089285910 cites W2079309430 @default.
- W3089285910 cites W2080807519 @default.
- W3089285910 cites W2092896290 @default.
- W3089285910 cites W2113830209 @default.
- W3089285910 cites W2115571073 @default.
- W3089285910 cites W2122390352 @default.
- W3089285910 cites W2124376042 @default.
- W3089285910 cites W2136469953 @default.
- W3089285910 cites W2136616978 @default.
- W3089285910 cites W2139500170 @default.
- W3089285910 cites W2152179548 @default.
- W3089285910 cites W2152913164 @default.
- W3089285910 cites W2165334931 @default.
- W3089285910 cites W2170146596 @default.
- W3089285910 cites W2257328348 @default.
- W3089285910 cites W2318906048 @default.
- W3089285910 cites W2444137400 @default.
- W3089285910 cites W2444425410 @default.
- W3089285910 cites W2519025924 @default.
- W3089285910 cites W2620764918 @default.
- W3089285910 cites W2724701326 @default.
- W3089285910 cites W2762969957 @default.
- W3089285910 cites W2763202890 @default.
- W3089285910 cites W2790841425 @default.
- W3089285910 cites W2797712042 @default.
- W3089285910 cites W2803414808 @default.
- W3089285910 cites W2928520695 @default.
- W3089285910 cites W2973146481 @default.
- W3089285910 cites W2982361299 @default.
- W3089285910 cites W2995490648 @default.
- W3089285910 cites W3012453544 @default.
- W3089285910 cites W3034429131 @default.
- W3089285910 cites W3035812912 @default.
- W3089285910 cites W3089441279 @default.
- W3089285910 cites W4233641566 @default.
- W3089285910 cites W4243900942 @default.
- W3089285910 doi "https://doi.org/10.3390/pharmaceutics12100908" @default.
- W3089285910 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7598194" @default.
- W3089285910 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32977559" @default.
- W3089285910 hasPublicationYear "2020" @default.
- W3089285910 type Work @default.
- W3089285910 sameAs 3089285910 @default.
- W3089285910 citedByCount "8" @default.
- W3089285910 countsByYear W30892859102021 @default.
- W3089285910 countsByYear W30892859102022 @default.
- W3089285910 countsByYear W30892859102023 @default.
- W3089285910 crossrefType "journal-article" @default.
- W3089285910 hasAuthorship W3089285910A5023520269 @default.
- W3089285910 hasAuthorship W3089285910A5051567097 @default.
- W3089285910 hasAuthorship W3089285910A5058057231 @default.
- W3089285910 hasAuthorship W3089285910A5065833268 @default.
- W3089285910 hasAuthorship W3089285910A5075293871 @default.