FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3089289552> ?p ?o ?g. }

• W3089289552 endingPage "1500" @default.
• W3089289552 startingPage "1489" @default.
• W3089289552 abstract "Intercellular adhesion of keratinocytes depends critically on desmosomes that, during maturation, acquire a hyperadhesive and thus Ca2+ independent state. Here, we investigated the roles of desmoglein (Dsg) 3 and plakophilins (Pkps) in hyperadhesion. Atomic force microscopy single molecule force mappings revealed increased Dsg3 molecules but not Dsg1 molecules binding strength in murine keratinocytes. However, keratinocytes lacking Dsg3 or Pkp1 or 3 revealed reduced Ca2+ independency. In addition, Pkp1- or 3-deficient keratinocytes did not exhibit changes in Dsg3 binding on the molecular level. Further, wild-type keratinocytes showed increased levels of Dsg3 oligomers during acquisition of hyperadhesion, and Pkp1 deficiency abolished the formation of Ca2+ independent Dsg3 oligomers. In concordance, immunostaining for Dsg1 but not for Dsg3 was reduced after 24 h of Ca2+ chelation in an ex vivo human skin model, suggesting that desmosomal cadherins may have different roles during acquisition of hyperadhesion. Taken together, these data indicate that hyperadhesion may not be a state acquired by entire desmosomes but rather is paralleled by enhanced binding of specific Dsg isoforms such as Dsg3, a process for which plaque proteins including Pkp 1 and 3 are required as well." @default.
• W3089289552 created "2020-10-01" @default.
• W3089289552 creator A5006765571 @default.
• W3089289552 creator A5063443015 @default.
• W3089289552 creator A5066754134 @default.
• W3089289552 creator A5073622338 @default.
• W3089289552 date "2020-10-01" @default.
• W3089289552 modified "2023-10-09" @default.
• W3089289552 title "Desmosomal Hyperadhesion Is Accompanied with Enhanced Binding Strength of Desmoglein 3 Molecules" @default.
• W3089289552 cites W1606958443 @default.
• W3089289552 cites W1944331545 @default.
• W3089289552 cites W1972937019 @default.
• W3089289552 cites W1976207239 @default.
• W3089289552 cites W1978932874 @default.
• W3089289552 cites W1984870208 @default.
• W3089289552 cites W1994430704 @default.
• W3089289552 cites W1997318519 @default.
• W3089289552 cites W2005111877 @default.
• W3089289552 cites W2005545805 @default.
• W3089289552 cites W2008400971 @default.
• W3089289552 cites W2010572700 @default.
• W3089289552 cites W2018094687 @default.
• W3089289552 cites W2026577172 @default.
• W3089289552 cites W2028766225 @default.
• W3089289552 cites W2028851968 @default.
• W3089289552 cites W2029131812 @default.
• W3089289552 cites W2030720251 @default.
• W3089289552 cites W2049759829 @default.
• W3089289552 cites W2052192720 @default.
• W3089289552 cites W2058092703 @default.
• W3089289552 cites W2073664099 @default.
• W3089289552 cites W2080344302 @default.
• W3089289552 cites W2092574258 @default.
• W3089289552 cites W2098951734 @default.
• W3089289552 cites W2116499729 @default.
• W3089289552 cites W2118289168 @default.
• W3089289552 cites W2127935695 @default.
• W3089289552 cites W2130505163 @default.
• W3089289552 cites W2133566253 @default.
• W3089289552 cites W2152401146 @default.
• W3089289552 cites W2152773840 @default.
• W3089289552 cites W2154953216 @default.
• W3089289552 cites W2157800624 @default.
• W3089289552 cites W2170737085 @default.
• W3089289552 cites W2179218090 @default.
• W3089289552 cites W2263422143 @default.
• W3089289552 cites W2432757814 @default.
• W3089289552 cites W2471536562 @default.
• W3089289552 cites W2578370456 @default.
• W3089289552 cites W2622476918 @default.
• W3089289552 cites W2752304619 @default.
• W3089289552 cites W2783972123 @default.
• W3089289552 cites W2789647325 @default.
• W3089289552 cites W2794407606 @default.
• W3089289552 cites W2794443774 @default.
• W3089289552 cites W2902892079 @default.
• W3089289552 cites W2904387391 @default.
• W3089289552 cites W2909797188 @default.
• W3089289552 cites W2931312254 @default.
• W3089289552 cites W2945047156 @default.
• W3089289552 cites W2998631974 @default.
• W3089289552 cites W39042124 @default.
• W3089289552 cites W4206388858 @default.
• W3089289552 cites W4232058283 @default.
• W3089289552 doi "https://doi.org/10.1016/j.bpj.2020.09.008" @default.
• W3089289552 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7642361" @default.
• W3089289552 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33031738" @default.
• W3089289552 hasPublicationYear "2020" @default.
• W3089289552 type Work @default.
• W3089289552 sameAs 3089289552 @default.
• W3089289552 citedByCount "9" @default.
• W3089289552 countsByYear W30892895522021 @default.
• W3089289552 countsByYear W30892895522022 @default.
• W3089289552 countsByYear W30892895522023 @default.
• W3089289552 crossrefType "journal-article" @default.
• W3089289552 hasAuthorship W3089289552A5006765571 @default.
• W3089289552 hasAuthorship W3089289552A5063443015 @default.
• W3089289552 hasAuthorship W3089289552A5066754134 @default.
• W3089289552 hasAuthorship W3089289552A5073622338 @default.
• W3089289552 hasBestOaLocation W30892895521 @default.
• W3089289552 hasConcept C102951782 @default.
• W3089289552 hasConcept C12554922 @default.
• W3089289552 hasConcept C1491633281 @default.
• W3089289552 hasConcept C149402561 @default.
• W3089289552 hasConcept C159654299 @default.
• W3089289552 hasConcept C163764329 @default.
• W3089289552 hasConcept C171250308 @default.
• W3089289552 hasConcept C185592680 @default.
• W3089289552 hasConcept C192562407 @default.
• W3089289552 hasConcept C203014093 @default.
• W3089289552 hasConcept C204232928 @default.
• W3089289552 hasConcept C2778757060 @default.
• W3089289552 hasConcept C2779075594 @default.
• W3089289552 hasConcept C2909223747 @default.
• W3089289552 hasConcept C2910519024 @default.
• W3089289552 hasConcept C4224716 @default.
• W3089289552 hasConcept C55493867 @default.
• W3089289552 hasConcept C67326383 @default.

• next