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- W3089297445 abstract "Dendritic cells (DCs) and T cells play important roles in immune regulation, and modulating their function is an approach for developing preventive or therapeutic strategies against immune disorders. Herein, the effect of pterostilbene (PSB) (3′,5′-dimethoxy-resveratrol)—a resveratrol-related polyphenol found in blueberries—on immune regulation was evaluated. Using an in vitro co-culture system, PSB was found to exert the strongest inhibitory effect among all tested resveratrol derivatives on DC-mediated T cell proliferation; moreover, PSB treatment decreased the Th1 and Th17 populations and increased the regulatory T cell (Treg) population. Upon co-stimulation with anti-CD3 and anti-CD28 antibodies, PSB inhibited CD4+ T cell proliferation and differentiation into Th1 cells. Additionally, PSB acted on DCs to suppress the lipopolysaccharide-induced transactivation of genes encoding antigen presentation-related molecules and inflammatory cytokines by attenuating the DNA-binding ability of the transcription factor PU.1. Furthermore, PSB promoted DC-mediated Foxp3+ Treg differentiation, and PU.1 knockdown increased DC-induced Treg activity. Oral administration of PSB alleviated the symptoms of dextran sulfate sodium-induced colitis and decreased tumor necrosis factor-α expression in mice. Thus, PSB treatment ameliorates colonic inflammation." @default.
- W3089297445 created "2020-10-01" @default.
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- W3089297445 date "2020-09-22" @default.
- W3089297445 modified "2023-10-14" @default.
- W3089297445 title "Pterostilbene reduces colonic inflammation by suppressing dendritic cell activation and promoting regulatory T cell development" @default.
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- W3089297445 doi "https://doi.org/10.1096/fj.202001502r" @default.
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