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- W3089299619 endingPage "108008" @default.
- W3089299619 startingPage "108008" @default.
- W3089299619 abstract "Acanthamoeba sp. is a free living amoeba that causes severe, painful and fatal infections, viz. Acanthamoeba keratitis and granulomatous amoebic encephalitis among humans. Antimicrobial chemotherapy used against Acanthamoeba is toxic to human cells and show side effects as well. Infections due to Acanthamoeba also pose challenges towards currently used antimicrobial treatment including resistance and transformation of trophozoites to resistant cyst forms that can lead to recurrence of infection. Therapeutic agents targeting central nervous system infections caused by Acanthamoeba should be able to cross blood-brain barrier. Nanoparticles based drug delivery put forth an effective therapeutic method to overcome the limitations of currently used antimicrobial chemotherapy. In recent years, various researchers investigated the effectiveness of nanoparticles conjugated drug and/or naturally occurring plant compounds against both trophozoites and cyst form of Acanthamoeba. In the current review, a reasonable effort has been made to provide a comprehensive overview of various nanoparticles tested for their efficacy against Acanthamoeba. This review summarizes the noteworthy details of research performed to elucidate the effect of nanoparticles conjugated drugs against Acanthamoeba." @default.
- W3089299619 created "2020-10-01" @default.
- W3089299619 creator A5011762191 @default.
- W3089299619 creator A5015254224 @default.
- W3089299619 creator A5044285688 @default.
- W3089299619 creator A5055352400 @default.
- W3089299619 date "2020-11-01" @default.
- W3089299619 modified "2023-10-16" @default.
- W3089299619 title "Nanoparticles based therapeutic efficacy against Acanthamoeba: Updates and future prospect" @default.
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