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- W3089307410 endingPage "188436" @default.
- W3089307410 startingPage "188436" @default.
- W3089307410 abstract "EpCAM has long been known as a cell surface protein highly expressed in carcinomas. It has since become one of the key cancer biomarkers. Despite its high fame, its actual role in cancer development is still controversial. Beyond a flurry of correlative studies, which point either to a positive or a negative link with tumour progression, there has been surprisingly few studies on the actual cellular mechanisms of EpCAM and on their functional consequences. Clearly, EpCAM plays multiple important roles, in cell proliferation as well as in cell adhesion and migration. The two latter functions, directly relevant for metastasis, are the focus of this review. We attempt here to bring together the available experimental data to build a global coherent view of EpCAM functions. We also include in this overview EpCAM2/Trop2, the close relative of EpCAM. At the core of EpCAM (and EpCAM2/Trop2) function stands the ability to repress contractility of the actomyosin cell cortex. This activity appears to involve direct inhibition by EpCAM of members of the novel PKC family and of a specific downstream PKD-Erk cascade. We will discuss how this activity can result in a variety of adhesive and migratory phenotypes, thus potentially explaining at least part of the apparent inconsistencies between different studies. The picture remains fragmented, and we will highlight some of the conflicting evidence and the many unsolved issues, starting with the controversy around its original description as a cell-cell adhesion molecule." @default.
- W3089307410 created "2020-10-01" @default.
- W3089307410 creator A5067840428 @default.
- W3089307410 creator A5082557444 @default.
- W3089307410 date "2020-12-01" @default.
- W3089307410 modified "2023-10-13" @default.
- W3089307410 title "EpCAM cellular functions in adhesion and migration, and potential impact on invasion: A critical review" @default.
- W3089307410 cites W1543107147 @default.
- W3089307410 cites W181487094 @default.
- W3089307410 cites W1969519743 @default.
- W3089307410 cites W1973576056 @default.
- W3089307410 cites W1973812639 @default.
- W3089307410 cites W1974803036 @default.
- W3089307410 cites W1975074702 @default.
- W3089307410 cites W1976021779 @default.
- W3089307410 cites W1981234066 @default.
- W3089307410 cites W1981943594 @default.
- W3089307410 cites W1984484474 @default.
- W3089307410 cites W1984640799 @default.
- W3089307410 cites W1985858950 @default.
- W3089307410 cites W1986978780 @default.
- W3089307410 cites W1988134165 @default.
- W3089307410 cites W1991346408 @default.
- W3089307410 cites W1993127658 @default.
- W3089307410 cites W2003564623 @default.
- W3089307410 cites W2004104913 @default.
- W3089307410 cites W2004694953 @default.
- W3089307410 cites W2008786566 @default.
- W3089307410 cites W2009693910 @default.
- W3089307410 cites W2012245492 @default.
- W3089307410 cites W2012376126 @default.
- W3089307410 cites W2015734787 @default.
- W3089307410 cites W2017664010 @default.
- W3089307410 cites W2019284666 @default.
- W3089307410 cites W2031904940 @default.
- W3089307410 cites W2035312349 @default.
- W3089307410 cites W2038615849 @default.
- W3089307410 cites W2040605299 @default.
- W3089307410 cites W2040719899 @default.
- W3089307410 cites W2044689258 @default.
- W3089307410 cites W2055107026 @default.
- W3089307410 cites W2063186096 @default.
- W3089307410 cites W2070734444 @default.
- W3089307410 cites W2074570440 @default.
- W3089307410 cites W2080115585 @default.
- W3089307410 cites W2084520007 @default.
- W3089307410 cites W2087160021 @default.
- W3089307410 cites W2092032317 @default.
- W3089307410 cites W2093758129 @default.
- W3089307410 cites W2094583671 @default.
- W3089307410 cites W2095432971 @default.
- W3089307410 cites W2097417152 @default.
- W3089307410 cites W2098541096 @default.
- W3089307410 cites W2098583297 @default.
- W3089307410 cites W2104134360 @default.
- W3089307410 cites W2106328387 @default.
- W3089307410 cites W2107166597 @default.
- W3089307410 cites W2107552318 @default.
- W3089307410 cites W2109650221 @default.
- W3089307410 cites W2111865362 @default.
- W3089307410 cites W2112715338 @default.
- W3089307410 cites W2112723692 @default.
- W3089307410 cites W2113922475 @default.
- W3089307410 cites W2116136455 @default.
- W3089307410 cites W2116144898 @default.
- W3089307410 cites W2117029515 @default.
- W3089307410 cites W2122510434 @default.
- W3089307410 cites W2122557087 @default.
- W3089307410 cites W2126681184 @default.
- W3089307410 cites W2132846945 @default.
- W3089307410 cites W2133847945 @default.
- W3089307410 cites W2135040607 @default.
- W3089307410 cites W2137143355 @default.
- W3089307410 cites W2138249379 @default.
- W3089307410 cites W2139086163 @default.
- W3089307410 cites W2143124350 @default.
- W3089307410 cites W2147121751 @default.
- W3089307410 cites W2157651423 @default.
- W3089307410 cites W2159703296 @default.
- W3089307410 cites W2164444034 @default.
- W3089307410 cites W2166845840 @default.
- W3089307410 cites W2167870766 @default.
- W3089307410 cites W2172224583 @default.
- W3089307410 cites W2218722424 @default.
- W3089307410 cites W2311177000 @default.
- W3089307410 cites W2460085209 @default.
- W3089307410 cites W2517007838 @default.
- W3089307410 cites W2558772117 @default.
- W3089307410 cites W2573789295 @default.
- W3089307410 cites W2574119839 @default.
- W3089307410 cites W2577512618 @default.
- W3089307410 cites W2588414287 @default.
- W3089307410 cites W2597799700 @default.
- W3089307410 cites W2599331401 @default.
- W3089307410 cites W2604987403 @default.
- W3089307410 cites W2735094248 @default.
- W3089307410 cites W2748357291 @default.
- W3089307410 cites W2789085582 @default.