FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3089321243> ?p ?o ?g. }

• W3089321243 abstract "Renal ischemia reperfusion injury (IRI) after surgery may promote acute lung injury (ALI) by inducing an inflammatory response. However, the underlying molecular mechanism is still unclear. Studies have reported that inhibitor of κB kinase (IKK)e primarily regulates inflammation and cell proliferation. The present study aimed to investigate the regulatory role of IKKe in ALI in mice, in order to provide an experimental basis for preventing ALI following surgery‑induced renal IRI. C57BL/6J wild‑type (WT) and IKKe knockout (IKKe‑/‑) mice underwent bilateral renal pedicle occlusion. The plasma creatinine concentration, urea nitrogen level and lung wet‑to‑dry ratio were measured at baseline, and at 24 and 48 h after declamping. The histological localization and protein levels of inflammatory factors, such as tumor necrosis factor (TNF)‑α, interleukin (IL)‑1β and IL‑10, were analyzed in lung tissues. Subsequently, the interactions between IKKe and components of the nuclear factor (NF)‑κB pathway were studied. The results of the present study demonstrated that the IKKe‑/‑ groups displayed similar renal function but less pulmonary edema compared with that of the WT groups. The levels of proinflammatory factors in the lungs were significantly upregulated in WT mice compared with those in IKKe‑/‑ mice after IRI surgery. The NF‑κB pathway components and downstream factors were substantially upregulated in the WT groups after acute ischemic kidney injury, and these effects were significantly inhibited in the IKKe‑/‑ groups. Based on these data, the present study hypothesized that IKKe may serve a negative role in kidney‑lung crosstalk after renal IRI and may be a novel target for the treatment of patients with renal IRI." @default.
• W3089321243 created "2020-10-01" @default.
• W3089321243 creator A5003293441 @default.
• W3089321243 creator A5016196534 @default.
• W3089321243 creator A5055617627 @default.
• W3089321243 creator A5062253236 @default.
• W3089321243 creator A5068746768 @default.
• W3089321243 creator A5087243907 @default.
• W3089321243 date "2020-09-22" @default.
• W3089321243 modified "2023-09-26" @default.
• W3089321243 title "IKKε deficiency inhibits acute lung injury following renal ischemia reperfusion injury" @default.
• W3089321243 cites W1982782912 @default.
• W3089321243 cites W1986347387 @default.
• W3089321243 cites W1987375982 @default.
• W3089321243 cites W1998226806 @default.
• W3089321243 cites W2005049163 @default.
• W3089321243 cites W2008424074 @default.
• W3089321243 cites W2015960698 @default.
• W3089321243 cites W2017205453 @default.
• W3089321243 cites W2048521033 @default.
• W3089321243 cites W2051338691 @default.
• W3089321243 cites W2056669128 @default.
• W3089321243 cites W2077447212 @default.
• W3089321243 cites W2078642938 @default.
• W3089321243 cites W2081351081 @default.
• W3089321243 cites W2082162959 @default.
• W3089321243 cites W2084368529 @default.
• W3089321243 cites W2090457486 @default.
• W3089321243 cites W2094742966 @default.
• W3089321243 cites W2119589320 @default.
• W3089321243 cites W2122044177 @default.
• W3089321243 cites W2126698946 @default.
• W3089321243 cites W2134210258 @default.
• W3089321243 cites W2138233570 @default.
• W3089321243 cites W2138590480 @default.
• W3089321243 cites W2139791477 @default.
• W3089321243 cites W2142155616 @default.
• W3089321243 cites W2144223841 @default.
• W3089321243 cites W2144787399 @default.
• W3089321243 cites W2146056765 @default.
• W3089321243 cites W2161533677 @default.
• W3089321243 cites W2254511588 @default.
• W3089321243 cites W2327032681 @default.
• W3089321243 cites W2885380750 @default.
• W3089321243 doi "https://doi.org/10.3892/mmr.2020.11532" @default.
• W3089321243 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7533469" @default.
• W3089321243 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33000218" @default.
• W3089321243 hasPublicationYear "2020" @default.
• W3089321243 type Work @default.
• W3089321243 sameAs 3089321243 @default.
• W3089321243 citedByCount "1" @default.
• W3089321243 countsByYear W30893212432021 @default.
• W3089321243 crossrefType "journal-article" @default.
• W3089321243 hasAuthorship W3089321243A5003293441 @default.
• W3089321243 hasAuthorship W3089321243A5016196534 @default.
• W3089321243 hasAuthorship W3089321243A5055617627 @default.
• W3089321243 hasAuthorship W3089321243A5062253236 @default.
• W3089321243 hasAuthorship W3089321243A5068746768 @default.
• W3089321243 hasAuthorship W3089321243A5087243907 @default.
• W3089321243 hasBestOaLocation W30893212431 @default.
• W3089321243 hasConcept C126322002 @default.
• W3089321243 hasConcept C134018914 @default.
• W3089321243 hasConcept C164027704 @default.
• W3089321243 hasConcept C17991360 @default.
• W3089321243 hasConcept C203014093 @default.
• W3089321243 hasConcept C2776914184 @default.
• W3089321243 hasConcept C2777714996 @default.
• W3089321243 hasConcept C2778176769 @default.
• W3089321243 hasConcept C2780091579 @default.
• W3089321243 hasConcept C2780306776 @default.
• W3089321243 hasConcept C2780472472 @default.
• W3089321243 hasConcept C71924100 @default.
• W3089321243 hasConcept C98274493 @default.
• W3089321243 hasConceptScore W3089321243C126322002 @default.
• W3089321243 hasConceptScore W3089321243C134018914 @default.
• W3089321243 hasConceptScore W3089321243C164027704 @default.
• W3089321243 hasConceptScore W3089321243C17991360 @default.
• W3089321243 hasConceptScore W3089321243C203014093 @default.
• W3089321243 hasConceptScore W3089321243C2776914184 @default.
• W3089321243 hasConceptScore W3089321243C2777714996 @default.
• W3089321243 hasConceptScore W3089321243C2778176769 @default.
• W3089321243 hasConceptScore W3089321243C2780091579 @default.
• W3089321243 hasConceptScore W3089321243C2780306776 @default.
• W3089321243 hasConceptScore W3089321243C2780472472 @default.
• W3089321243 hasConceptScore W3089321243C71924100 @default.
• W3089321243 hasConceptScore W3089321243C98274493 @default.
• W3089321243 hasLocation W30893212431 @default.
• W3089321243 hasLocation W30893212432 @default.
• W3089321243 hasOpenAccess W3089321243 @default.
• W3089321243 hasPrimaryLocation W30893212431 @default.
• W3089321243 hasRelatedWork W10257988 @default.
• W3089321243 hasRelatedWork W10583791 @default.
• W3089321243 hasRelatedWork W11082109 @default.
• W3089321243 hasRelatedWork W11766024 @default.
• W3089321243 hasRelatedWork W1906851 @default.
• W3089321243 hasRelatedWork W19923964 @default.
• W3089321243 hasRelatedWork W62956 @default.
• W3089321243 hasRelatedWork W6705851 @default.
• W3089321243 hasRelatedWork W13460065 @default.
• W3089321243 hasRelatedWork W14094381 @default.

• next