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- W3089343310 abstract "The nucleation of microtubules from αβ-tubulin dimers is an essential cellular process dependent on γ-tubulin complexes. Mechanistic understanding of the nucleation reaction was hampered by the lack of γ-tubulin complex structures at sufficiently high resolution. The recent technical developments in cryo-electron microscopy have allowed resolving the vertebrate γ-tubulin ring complex (γ-TuRC) structure at near-atomic resolution. These studies clarified the arrangement and stoichiometry of gamma-tubulin complex proteins in the γ-TuRC, characterized the surprisingly versatile integration of the small proteins MZT1/2 into the complex, and identified actin as an integral component of the γ-TuRC. In this review, we summarize the structural insights into the molecular architecture, the assembly pathway, and the regulation of the microtubule nucleation reaction." @default.
- W3089343310 created "2020-10-08" @default.
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- W3089343310 date "2021-02-01" @default.
- W3089343310 modified "2023-09-26" @default.
- W3089343310 title "The structure of the γ-TuRC: a 25-years-old molecular puzzle" @default.
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- W3089343310 doi "https://doi.org/10.1016/j.sbi.2020.08.008" @default.
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