Matches in SemOpenAlex for { <https://semopenalex.org/work/W3089366329> ?p ?o ?g. }
Showing items 1 to 96 of
96
with 100 items per page.
- W3089366329 abstract "Abstract A large proportion of end-stage renal disease (ESRD) patients under long-term haemodialysis, have persistent anaemia and require high doses of recombinant human erythropoietin (rhEPO). However, the underlying mechanisms of renal anaemia have not been fully elucidated in these patients. In this study, we will be focusing on anaemia and plasma proteins in ESRD patients on high-flux haemodialysis (HF) and on-line haemodiafiltration (HDF), to investigate using two proteomic approaches if patients undergoing these treatments develop differences in their plasma protein composition and how this could be related to their anaemia. The demographic and biochemical data revealed that HDF patients had lower anaemia and much lower rhEPO requirements than HF patients. Regarding their plasma proteomes, HDF patients had increased levels of a protein highly similar to serotransferrin, trypsin-1 and immunoglobulin heavy constant chain alpha-1, and lower levels of alpha-1 antitrypsin, transthyretin, apolipoproteins E and C-III, and haptoglobin-related protein. Lower transthyretin levels in HDF patients were further confirmed by transthyretin-peptide quantification and western blot detection. Since ESRD patients have increased transthyretin, a protein that can aggregate and inhibit transferrin endocytosis and erythropoiesis, our finding that HDF patients have lower transthyretin and lower anaemia suggests that the decrease in transthyretin plasma levels would allow an increase in transferrin endocytosis, contributing to erythropoiesis. Thus, transthyretin could be a critical actor for anaemia in ESRD patients and a novel player for haemodialysis adequacy." @default.
- W3089366329 created "2020-10-08" @default.
- W3089366329 creator A5000992628 @default.
- W3089366329 creator A5016014915 @default.
- W3089366329 creator A5043868915 @default.
- W3089366329 creator A5057650956 @default.
- W3089366329 creator A5077003669 @default.
- W3089366329 creator A5079577793 @default.
- W3089366329 date "2020-09-29" @default.
- W3089366329 modified "2023-10-14" @default.
- W3089366329 title "Proteomic analysis of plasma proteins of high-flux haemodialysis and on-line haemodiafiltration patients reveals differences in transthyretin levels related with anaemia" @default.
- W3089366329 cites W1964742940 @default.
- W3089366329 cites W1976925012 @default.
- W3089366329 cites W1977783050 @default.
- W3089366329 cites W1991366673 @default.
- W3089366329 cites W2009192569 @default.
- W3089366329 cites W2055052221 @default.
- W3089366329 cites W2065522670 @default.
- W3089366329 cites W2069354437 @default.
- W3089366329 cites W2127876911 @default.
- W3089366329 cites W2139803981 @default.
- W3089366329 cites W2143345898 @default.
- W3089366329 cites W2152245439 @default.
- W3089366329 cites W2160521073 @default.
- W3089366329 cites W2304308035 @default.
- W3089366329 cites W2316265097 @default.
- W3089366329 cites W2407889154 @default.
- W3089366329 cites W2563186820 @default.
- W3089366329 cites W2586083234 @default.
- W3089366329 cites W2603888409 @default.
- W3089366329 cites W2761032010 @default.
- W3089366329 cites W2772547249 @default.
- W3089366329 cites W2772621049 @default.
- W3089366329 cites W2893019622 @default.
- W3089366329 cites W2895618979 @default.
- W3089366329 cites W2895697460 @default.
- W3089366329 cites W2917653738 @default.
- W3089366329 cites W4211062471 @default.
- W3089366329 doi "https://doi.org/10.1038/s41598-020-72104-5" @default.
- W3089366329 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7524835" @default.
- W3089366329 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32994444" @default.
- W3089366329 hasPublicationYear "2020" @default.
- W3089366329 type Work @default.
- W3089366329 sameAs 3089366329 @default.
- W3089366329 citedByCount "2" @default.
- W3089366329 countsByYear W30893663292021 @default.
- W3089366329 countsByYear W30893663292023 @default.
- W3089366329 crossrefType "journal-article" @default.
- W3089366329 hasAuthorship W3089366329A5000992628 @default.
- W3089366329 hasAuthorship W3089366329A5016014915 @default.
- W3089366329 hasAuthorship W3089366329A5043868915 @default.
- W3089366329 hasAuthorship W3089366329A5057650956 @default.
- W3089366329 hasAuthorship W3089366329A5077003669 @default.
- W3089366329 hasAuthorship W3089366329A5079577793 @default.
- W3089366329 hasBestOaLocation W30893663291 @default.
- W3089366329 hasConcept C121157162 @default.
- W3089366329 hasConcept C126322002 @default.
- W3089366329 hasConcept C134018914 @default.
- W3089366329 hasConcept C146543888 @default.
- W3089366329 hasConcept C206396517 @default.
- W3089366329 hasConcept C22814914 @default.
- W3089366329 hasConcept C2776125364 @default.
- W3089366329 hasConcept C2778534260 @default.
- W3089366329 hasConcept C71924100 @default.
- W3089366329 hasConceptScore W3089366329C121157162 @default.
- W3089366329 hasConceptScore W3089366329C126322002 @default.
- W3089366329 hasConceptScore W3089366329C134018914 @default.
- W3089366329 hasConceptScore W3089366329C146543888 @default.
- W3089366329 hasConceptScore W3089366329C206396517 @default.
- W3089366329 hasConceptScore W3089366329C22814914 @default.
- W3089366329 hasConceptScore W3089366329C2776125364 @default.
- W3089366329 hasConceptScore W3089366329C2778534260 @default.
- W3089366329 hasConceptScore W3089366329C71924100 @default.
- W3089366329 hasFunder F4320326262 @default.
- W3089366329 hasFunder F4320334923 @default.
- W3089366329 hasIssue "1" @default.
- W3089366329 hasLocation W30893663291 @default.
- W3089366329 hasLocation W30893663292 @default.
- W3089366329 hasLocation W30893663293 @default.
- W3089366329 hasOpenAccess W3089366329 @default.
- W3089366329 hasPrimaryLocation W30893663291 @default.
- W3089366329 hasRelatedWork W1833459588 @default.
- W3089366329 hasRelatedWork W1928099904 @default.
- W3089366329 hasRelatedWork W1951419200 @default.
- W3089366329 hasRelatedWork W2146030096 @default.
- W3089366329 hasRelatedWork W2399233676 @default.
- W3089366329 hasRelatedWork W2400360970 @default.
- W3089366329 hasRelatedWork W2403954041 @default.
- W3089366329 hasRelatedWork W2410733185 @default.
- W3089366329 hasRelatedWork W2412421558 @default.
- W3089366329 hasRelatedWork W2413374907 @default.
- W3089366329 hasVolume "10" @default.
- W3089366329 isParatext "false" @default.
- W3089366329 isRetracted "false" @default.
- W3089366329 magId "3089366329" @default.
- W3089366329 workType "article" @default.