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• W3089398966 endingPage "762" @default.
• W3089398966 startingPage "740" @default.
• W3089398966 abstract "ABSTRACT The environmental species Pseudomonas aeruginosa thrives in a variety of habitats. Within the epidemic population structure of P. aeruginosa, occassionally highly successful clones that are equally capable to succeed in the environment and the human host arise. Framed by a highly conserved core genome, individual members of successful clones are characterized by a high variability in their accessory genome. The abundance of successful clones might be funded in specific features of the core genome or, although not mutually exclusive, in the variability of the accessory genome. In clone C, one of the most predominant clones, the plasmid pKLC102 and the PACGI-1 genomic island are two ubiquitous accessory genetic elements. The conserved transmissible locus of protein quality control (TLPQC) at the border of PACGI-1 is a unique horizontally transferred compository element, which codes predominantly for stress-related cargo gene products such as involved in protein homeostasis. As a hallmark, most TLPQC xenologues possess a core genome equivalent. With elevated temperature tolerance as a characteristic of clone C strains, the unique P. aeruginosa and clone C specific disaggregase ClpG is a major contributor to tolerance. As other successful clones, such as PA14, do not encode the TLPQC locus, ubiquitous denominators of success, if existing, need to be identified." @default.
• W3089398966 created "2020-10-08" @default.
• W3089398966 creator A5000556766 @default.
• W3089398966 creator A5015116259 @default.
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• W3089398966 creator A5027874186 @default.
• W3089398966 creator A5039898587 @default.
• W3089398966 creator A5041981028 @default.
• W3089398966 date "2020-09-29" @default.
• W3089398966 modified "2023-10-17" @default.
• W3089398966 title "Why? – Successful <i>Pseudomonas aeruginosa</i> clones with a focus on clone C" @default.
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