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- W3089400930 endingPage "3261" @default.
- W3089400930 startingPage "3243" @default.
- W3089400930 abstract "Structural biologists have traditionally approached cellular complexity in a reductionist manner in which the cellular molecular components are fractionated and purified before being studied individually. This ‘divide and conquer’ approach has been highly successful. However, awareness has grown in recent years that biological functions can rarely be attributed to individual macromolecules. Most cellular functions arise from their concerted action, and there is thus a need for methods enabling structural studies performed in situ, ideally in unperturbed cellular environments. Cryo-electron tomography (Cryo-ET) combines the power of 3D molecular-level imaging with the best structural preservation that is physically possible to achieve. Thus, it has a unique potential to reveal the supramolecular architecture or ‘molecular sociology’ of cells and to discover the unexpected. Here, we review state-of-the-art Cryo-ET workflows, provide examples of biological applications, and discuss what is needed to realize the full potential of Cryo-ET." @default.
- W3089400930 created "2020-10-08" @default.
- W3089400930 creator A5029559203 @default.
- W3089400930 creator A5081479060 @default.
- W3089400930 date "2020-10-01" @default.
- W3089400930 modified "2023-10-15" @default.
- W3089400930 title "The promise and the challenges of cryo‐electron tomography" @default.
- W3089400930 cites W139131824 @default.
- W3089400930 cites W1579186192 @default.
- W3089400930 cites W1948710406 @default.
- W3089400930 cites W1967008529 @default.
- W3089400930 cites W1971411282 @default.
- W3089400930 cites W1978288593 @default.
- W3089400930 cites W1978485708 @default.
- W3089400930 cites W1989521332 @default.
- W3089400930 cites W1989585427 @default.
- W3089400930 cites W1991815226 @default.
- W3089400930 cites W1992709537 @default.
- W3089400930 cites W1994582860 @default.
- W3089400930 cites W1995648222 @default.
- W3089400930 cites W1996074267 @default.
- W3089400930 cites W2001024934 @default.
- W3089400930 cites W2001735605 @default.
- W3089400930 cites W2001828266 @default.
- W3089400930 cites W2002924743 @default.
- W3089400930 cites W2003054791 @default.
- W3089400930 cites W2003256580 @default.
- W3089400930 cites W2003294049 @default.
- W3089400930 cites W2005240547 @default.
- W3089400930 cites W2009040652 @default.
- W3089400930 cites W2014572457 @default.
- W3089400930 cites W2016314394 @default.
- W3089400930 cites W2016365913 @default.
- W3089400930 cites W2017292564 @default.
- W3089400930 cites W2020435927 @default.
- W3089400930 cites W2020510568 @default.
- W3089400930 cites W2023721493 @default.
- W3089400930 cites W2026713364 @default.
- W3089400930 cites W2028605946 @default.
- W3089400930 cites W2039175603 @default.
- W3089400930 cites W2042455841 @default.
- W3089400930 cites W2045671533 @default.
- W3089400930 cites W2045792648 @default.
- W3089400930 cites W2046164706 @default.
- W3089400930 cites W2046542456 @default.
- W3089400930 cites W2049137651 @default.
- W3089400930 cites W2052152321 @default.
- W3089400930 cites W2054520331 @default.
- W3089400930 cites W2056823255 @default.
- W3089400930 cites W2061835758 @default.
- W3089400930 cites W2066828546 @default.
- W3089400930 cites W2067987159 @default.
- W3089400930 cites W2073949924 @default.
- W3089400930 cites W2074021149 @default.
- W3089400930 cites W2075824676 @default.
- W3089400930 cites W2076710572 @default.
- W3089400930 cites W2079123529 @default.
- W3089400930 cites W2081460107 @default.
- W3089400930 cites W2082088930 @default.
- W3089400930 cites W2083019919 @default.
- W3089400930 cites W2086386721 @default.
- W3089400930 cites W2086643161 @default.
- W3089400930 cites W2087960949 @default.
- W3089400930 cites W2103972113 @default.
- W3089400930 cites W2106393979 @default.
- W3089400930 cites W2115251427 @default.
- W3089400930 cites W2122151115 @default.
- W3089400930 cites W2123176293 @default.
- W3089400930 cites W2123207418 @default.
- W3089400930 cites W2125798809 @default.
- W3089400930 cites W2126919547 @default.
- W3089400930 cites W2130837903 @default.
- W3089400930 cites W2139066576 @default.
- W3089400930 cites W2143368436 @default.
- W3089400930 cites W2148941629 @default.
- W3089400930 cites W2155539714 @default.
- W3089400930 cites W2159693730 @default.
- W3089400930 cites W2165493192 @default.
- W3089400930 cites W2165962849 @default.
- W3089400930 cites W2172110248 @default.
- W3089400930 cites W2178041119 @default.
- W3089400930 cites W2210370832 @default.
- W3089400930 cites W2219169508 @default.
- W3089400930 cites W2220896177 @default.
- W3089400930 cites W2235248450 @default.
- W3089400930 cites W2256496133 @default.
- W3089400930 cites W2264619615 @default.
- W3089400930 cites W2265299935 @default.
- W3089400930 cites W2279402243 @default.
- W3089400930 cites W2292820626 @default.
- W3089400930 cites W2311730650 @default.
- W3089400930 cites W2330785519 @default.
- W3089400930 cites W2336360858 @default.
- W3089400930 cites W2346185129 @default.
- W3089400930 cites W2427061751 @default.
- W3089400930 cites W2466664260 @default.
- W3089400930 cites W2466725324 @default.
- W3089400930 cites W2487704570 @default.