Matches in SemOpenAlex for { <https://semopenalex.org/work/W3089433263> ?p ?o ?g. }
- W3089433263 endingPage "57" @default.
- W3089433263 startingPage "1" @default.
- W3089433263 abstract "Long non-coding (lnc) RNAs are vital regulators of a plethora of biological processes. They have been shown to play major roles as transcriptional and post-transcriptional regulators, with some being involved in imprinting genomic loci, shaping chromosome conformation and allosteric regulation of protein activities. Highly specific patterns of lncRNA expression coordinate cellular differentiation, pluripotency, and development; while the overexpression, deficiency, or mutation of lncRNA genes have been implicated in numerous disorders. Given the diversity and number of lncRNAs, it seems likely that their functions are as numerous as those of proteins, yet, only a small fraction of these transcripts have been structurally and functionally characterized. Although the vast majority of information regarding lncRNA structure and function is derived based on the studies of human lncRNAs, in recent years, these transcripts have been identified in plants, bacteria, and viruses. This chapter aims to overview the salient features, biogenesis, and biological importance of these molecules in various biological systems. We discuss a few prominent examples of lncRNAs expressed in humans, plants, bacteria, and viruses, highlighting their structural properties, physiological functions, and modes of action. There are still many questions that need to be addressed in this relatively new research area. Addressing them in the future research will enhance our knowledge of RNA plasticity as a biological control mechanism and potentially discover novel targets to control the biological outputs of cellular processes in response to different stimuli." @default.
- W3089433263 created "2020-10-08" @default.
- W3089433263 creator A5018261951 @default.
- W3089433263 creator A5032923003 @default.
- W3089433263 creator A5088841611 @default.
- W3089433263 date "2020-01-01" @default.
- W3089433263 modified "2023-09-25" @default.
- W3089433263 title "Long Non-coding RNAs Diversity in Form and Function: From Microbes to Humans" @default.
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