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- W3089441201 endingPage "2547" @default.
- W3089441201 startingPage "2535" @default.
- W3089441201 abstract "Abstract The brain renin–angiotensin system (RAS) plays an important role in the regulation of autonomic and neuroendocrine functions, and maintains cardiovascular homeostasis. Ang-II is the major effector molecule of RAS and exerts most of its physiological functions, including blood pressure (BP) regulation, via activation of AT1 receptors. Dysregulation of brain RAS in the central nervous system results in increased Ang-II synthesis that leads to sympathetic outflow and hypertension. Brain angiotensin (Ang) converting enzyme-2 (ACE2) was discovered two decades ago as an RAS component, exhibiting a counter-regulatory role and opposing the adverse cardiovascular effects produced by Ang-II. Studies using synthetic compounds that can sustain the elevation of ACE2 activity or genetically overexpressed ACE2 in specific brain regions found various beneficial effects on cardiovascular function. More recently, ACE2 has been shown to play critical roles in neuro-inflammation, gut dysbiosis and the regulation of stress and anxiety-like behaviors. In the present review, we aim to highlight the anatomical locations and functional implication of brain ACE2 related to its BP regulation via modulation of the sympathetic nervous system and discuss the recent developments and future directions in the ACE2-mediated central cardiovascular regulation." @default.
- W3089441201 created "2020-10-08" @default.
- W3089441201 creator A5004261181 @default.
- W3089441201 creator A5013410313 @default.
- W3089441201 creator A5050387959 @default.
- W3089441201 date "2020-10-01" @default.
- W3089441201 modified "2023-10-01" @default.
- W3089441201 title "Brain angiotensin converting enzyme-2 in central cardiovascular regulation" @default.
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