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- W3089463738 abstract "Abstract Utilizing a chiral bicyclic imidazole organocatalyst and adopting a continuous injection process, an alternative route has been developed for the efficient synthesis of chiral phthalidyl ester prodrugs via dynamic kinetic resolution of 3‐hydroxyphthalides through enantioselective acylation (up to 99 % ee ). The computational studies suggest a general base catalytic mechanism differing from the widely accepted nucleophilic catalytic mechanism. The structure analysis of the key transition states shows that the CH‐π interactions and not the previously considered cation/π‐π interactions between the catalyst and substrate is the dominant factor giving rise to the observed stereocontrol." @default.
- W3089463738 created "2020-10-08" @default.
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- W3089463738 date "2020-11-17" @default.
- W3089463738 modified "2023-10-15" @default.
- W3089463738 title "Chiral Bicyclic Imidazole‐Catalyzed Acylative Dynamic Kinetic Resolution for the Synthesis of Chiral Phthalidyl Esters" @default.
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- W3089463738 doi "https://doi.org/10.1002/anie.202012445" @default.
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