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- W3089473423 abstract "Digit tip regeneration is one of the few examples of true multi-tissue regeneration in an adult mammal. The key step in this process is the formation of the blastema, a transient proliferating cell mass that generates the different cell types of the digit to replicate the original structure. Failure to form the blastema results in a lack of regeneration and has been postulated to be the reason why mammalian limbs cannot regrow following amputation. Understanding how the blastema forms and functions will help us to determine what is required for mammalian regeneration to occur and will provide insights into potential therapies for mammalian tissue regeneration and repair. This review summarizes the cellular and molecular mechanisms that influence murine blastema formation and govern digit tip regeneration." @default.
- W3089473423 created "2020-10-08" @default.
- W3089473423 creator A5037585395 @default.
- W3089473423 creator A5049519375 @default.
- W3089473423 date "2020-09-01" @default.
- W3089473423 modified "2023-10-12" @default.
- W3089473423 title "Cellular and molecular mechanisms that regulate mammalian digit tip regeneration" @default.
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- W3089473423 doi "https://doi.org/10.1098/rsob.200194" @default.
- W3089473423 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7536070" @default.
- W3089473423 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32993414" @default.
- W3089473423 hasPublicationYear "2020" @default.
- W3089473423 type Work @default.
- W3089473423 sameAs 3089473423 @default.