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• W3089478210 endingPage "100980" @default.
• W3089478210 startingPage "100980" @default.
• W3089478210 abstract "• Biomimetic micro/nano structures for biomedical applications are overviewed. • Fundamental and guiding principles for of micro/nano structures are summarized. • The wide application of micro/nano structures in vitiro and in vivo are discussed. • Perspectives towards biomimetic micro/nano structures are outlooked. Cell behaviors are influenced by the surrounding dynamic microenvironment where the extracellular matrix (ECM) composed of different micro/nano-structures plays a key role. Many micro/nano-structures have been developed to mimic the structure of ECM, but these structures are almost static, and fail to emulate the dynamicity and function of the ECM in vivo . Notably, certain micro/nano-structures based on shape-memory polymers (SMPs), including patterns, fibers, porous scaffolds and microspheres, have attracted increasing attention due to the unique spatiotemporal variations. The dynamical shifting of these biomimetic micro/nano-structures arising from the shape-memory effect endows the materials with unique functions, e.g. , regulating cell behaviors and prompting tissue growth. Therefore, the dynamically tunable biomimetic micro/nano-structures based on SMPs can be an ideal platform to mimic dynamic changes in the ECM structure both in vitro and in vivo . This review summarizes the latest advances in the development of the methodologies for fabricating various SMP biomimetic micro/nano structures, spatiotemporal control of cell behaviors, and broad applications in biomedical engineering. Several crucial points for future research are presented." @default.
• W3089478210 created "2020-10-08" @default.
• W3089478210 creator A5003372705 @default.
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• W3089478210 creator A5015981279 @default.
• W3089478210 creator A5063688245 @default.
• W3089478210 creator A5071539566 @default.
• W3089478210 date "2020-12-01" @default.
• W3089478210 modified "2023-10-11" @default.
• W3089478210 title "Biomimetic micro/nano structures for biomedical applications" @default.
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