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• W3089497979 abstract "Background Precisely engineered mesoporous silica has been shown to induce weight loss in mice, but whether it is safe to use in humans have not investigated. Objective The aim was to determine whether oral dosing, up to 9 grams/day, of precisely engineered mesoporous silica as a food additive can be used safely in male humans. Design This single blinded safety study consisted of two study arms including 10 males each (18–35 years). One arm consisted of participants with normal weight and one with obesity. After a placebo run-in period, all subjects were given porous silica three times daily, with increasing dose up to 9 grams/day (Phase 1). Subjects with obesity continued the study with highest dose for additional 10 weeks (Phase 2). Results All participants completed Phase 1 and 90% completed Phase 2, with approximately 1% missed doses. Participants reported no abdominal discomfort, and changes in bowel habits were minor and inconsistent. The side effects observed were mild and tolerable, biomarkers did not give any safety concern, and no severe adverse events occurred. Conclusion Mesoporous silica intake of up to 9 grams/day can be consumed by males without any major adverse events or safety concerns." @default.
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• W3089497979 date "2020-10-02" @default.
• W3089497979 modified "2023-10-15" @default.
• W3089497979 title "Oral intake of mesoporous silica is safe and well tolerated in male humans" @default.
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• W3089497979 doi "https://doi.org/10.1371/journal.pone.0240030" @default.
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