FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3089548110> ?p ?o ?g. }

• W3089548110 endingPage "686" @default.
• W3089548110 startingPage "677" @default.
• W3089548110 abstract "Objective Thiopurines are widely used as maintenance therapy in inflammatory bowel disease (IBD) but the evidence base for their use is sparse and their role increasingly questioned. Using the largest series reported to date, we assessed the long-term effectiveness of thiopurines in ulcerative colitis (UC) and Crohn’s disease (CD), including their impact on need for surgery. Design Outcomes were assessed in 11 928 patients (4968 UC, 6960 CD) in the UK IBD BioResource initiated on thiopurine monotherapy with the intention of maintaining medically induced remission. Effectiveness was assessed retrospectively using patient-level data and a definition that required avoidance of escalation to biological therapy or surgery while on thiopurines. Analyses included overall effectiveness, time-to-event analysis for treatment escalation and comparison of surgery rates in patients tolerant or intolerant of thiopurines. Results Using 68 132 patient-years of exposure, thiopurine monotherapy appeared effective for the duration of treatment in 2617/4968 (52.7%) patients with UC compared with 2378/6960 (34.2%) patients with CD (p<0.0001). This difference was corroborated in a multivariable analysis: after adjusting for variables including treatment era, thiopurine monotherapy was less effective in CD than UC (OR 0.47, 95% CI 0.43 to 0.51, p<0.0001). Thiopurine intolerance was associated with increased risk of surgery in UC (HR 2.44, p<0.0001); with a more modest impact on need for surgery in CD (HR=1.23, p=0.0015). Conclusion Thiopurine monotherapy is an effective long-term treatment for UC but significantly less effective in CD." @default.
• W3089548110 created "2020-10-08" @default.
• W3089548110 creator A5004790038 @default.
• W3089548110 creator A5009194147 @default.
• W3089548110 creator A5016296980 @default.
• W3089548110 creator A5022131173 @default.
• W3089548110 creator A5024744790 @default.
• W3089548110 creator A5061023789 @default.
• W3089548110 creator A5066218040 @default.
• W3089548110 creator A5075077889 @default.
• W3089548110 date "2020-10-01" @default.
• W3089548110 modified "2023-10-17" @default.
• W3089548110 title "Thiopurine monotherapy is effective in ulcerative colitis but significantly less so in Crohn’s disease: long-term outcomes for 11 928 patients in the UK inflammatory bowel disease bioresource" @default.
• W3089548110 cites W11751951 @default.
• W3089548110 cites W1499566049 @default.
• W3089548110 cites W1612648896 @default.
• W3089548110 cites W1974258746 @default.
• W3089548110 cites W1978683701 @default.
• W3089548110 cites W1997402233 @default.
• W3089548110 cites W2000368489 @default.
• W3089548110 cites W2001778936 @default.
• W3089548110 cites W2003681655 @default.
• W3089548110 cites W2008792881 @default.
• W3089548110 cites W2010469688 @default.
• W3089548110 cites W2012375240 @default.
• W3089548110 cites W2013064714 @default.
• W3089548110 cites W2014352723 @default.
• W3089548110 cites W2032965564 @default.
• W3089548110 cites W203984136 @default.
• W3089548110 cites W2043258441 @default.
• W3089548110 cites W2047212658 @default.
• W3089548110 cites W2049974164 @default.
• W3089548110 cites W2059964008 @default.
• W3089548110 cites W2070852224 @default.
• W3089548110 cites W2086876472 @default.
• W3089548110 cites W2102242005 @default.
• W3089548110 cites W2106733239 @default.
• W3089548110 cites W2108236283 @default.
• W3089548110 cites W2109479417 @default.
• W3089548110 cites W2110431279 @default.
• W3089548110 cites W2122527047 @default.
• W3089548110 cites W2126807394 @default.
• W3089548110 cites W2127664523 @default.
• W3089548110 cites W2128173849 @default.
• W3089548110 cites W2150935173 @default.
• W3089548110 cites W2153190211 @default.
• W3089548110 cites W2154875222 @default.
• W3089548110 cites W2314055620 @default.
• W3089548110 cites W2322616832 @default.
• W3089548110 cites W2410520654 @default.
• W3089548110 cites W2587232180 @default.
• W3089548110 cites W2626370788 @default.
• W3089548110 cites W2767910653 @default.
• W3089548110 cites W2791961467 @default.
• W3089548110 cites W2795525416 @default.
• W3089548110 cites W2809296974 @default.
• W3089548110 cites W2895055937 @default.
• W3089548110 cites W2900857121 @default.
• W3089548110 cites W2916794721 @default.
• W3089548110 cites W2949937340 @default.
• W3089548110 cites W2951715775 @default.
• W3089548110 cites W2976362764 @default.
• W3089548110 doi "https://doi.org/10.1136/gutjnl-2019-320185" @default.
• W3089548110 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7948184" @default.
• W3089548110 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33004550" @default.
• W3089548110 hasPublicationYear "2020" @default.
• W3089548110 type Work @default.
• W3089548110 sameAs 3089548110 @default.
• W3089548110 citedByCount "35" @default.
• W3089548110 countsByYear W30895481102020 @default.
• W3089548110 countsByYear W30895481102021 @default.
• W3089548110 countsByYear W30895481102022 @default.
• W3089548110 countsByYear W30895481102023 @default.
• W3089548110 crossrefType "journal-article" @default.
• W3089548110 hasAuthorship W3089548110A5004790038 @default.
• W3089548110 hasAuthorship W3089548110A5009194147 @default.
• W3089548110 hasAuthorship W3089548110A5016296980 @default.
• W3089548110 hasAuthorship W3089548110A5022131173 @default.
• W3089548110 hasAuthorship W3089548110A5024744790 @default.
• W3089548110 hasAuthorship W3089548110A5061023789 @default.
• W3089548110 hasAuthorship W3089548110A5066218040 @default.
• W3089548110 hasAuthorship W3089548110A5075077889 @default.
• W3089548110 hasBestOaLocation W30895481101 @default.
• W3089548110 hasConcept C126322002 @default.
• W3089548110 hasConcept C2776760755 @default.
• W3089548110 hasConcept C2778260677 @default.
• W3089548110 hasConcept C2779134260 @default.
• W3089548110 hasConcept C2779280984 @default.
• W3089548110 hasConcept C2780479503 @default.
• W3089548110 hasConcept C70917649 @default.
• W3089548110 hasConcept C71924100 @default.
• W3089548110 hasConcept C90924648 @default.
• W3089548110 hasConceptScore W3089548110C126322002 @default.
• W3089548110 hasConceptScore W3089548110C2776760755 @default.
• W3089548110 hasConceptScore W3089548110C2778260677 @default.
• W3089548110 hasConceptScore W3089548110C2779134260 @default.
• W3089548110 hasConceptScore W3089548110C2779280984 @default.
• W3089548110 hasConceptScore W3089548110C2780479503 @default.

• next