Matches in SemOpenAlex for { <https://semopenalex.org/work/W3089551412> ?p ?o ?g. }
- W3089551412 endingPage "4875" @default.
- W3089551412 startingPage "4863" @default.
- W3089551412 abstract "The d- and l-forms of lactate are important fermentation metabolites produced by intestinal bacteria but are found to negatively affect mucosal barrier function and human health. Both enantiomers of lactate can be converted with acetate into the presumed beneficial butyrate by a phylogenetically related group of anaerobes, including Anaerobutyricum and Anaerostipes spp. This is a low energy yielding process with a partially unknown pathway in Anaerobutyricum and Anaerostipes spp. and hence, we sought to address this via a comparative genomics, proteomics and physiology approach. We compared growth of Anaerobutyricum soehngenii on lactate with that on sucrose and sorbitol. Comparative proteomics revealed complete pathway of butyrate formation from sucrose, sorbitol and lactate. Notably, a gene cluster, lctABCDEF was abundantly expressed when grown on lactate. This gene cluster encodes a lactate dehydrogenase (lctD), electron transport proteins A and B (lctCB), nickel-dependent racemase (lctE), lactate permease (lctF) and short-chain acyl-CoA dehydrogenase (lctG). Investigation of available genomes of intestinal bacteria revealed this new gene cluster to be highly conserved in only Anaerobutyricum and Anaerostipes spp. Present study demonstrates that A. soehngenii and several related Anaerobutyricum and Anaerostipes spp. are highly adapted for a lifestyle involving lactate plus acetate utilization in the human intestinal tract." @default.
- W3089551412 created "2020-10-08" @default.
- W3089551412 creator A5005546551 @default.
- W3089551412 creator A5011335306 @default.
- W3089551412 creator A5014776360 @default.
- W3089551412 creator A5054572740 @default.
- W3089551412 creator A5068718584 @default.
- W3089551412 date "2020-10-12" @default.
- W3089551412 modified "2023-10-16" @default.
- W3089551412 title "Unravelling lactate‐acetate and sugar conversion into butyrate by intestinal <i>Anaerobutyricum</i> and <i>Anaerostipes</i> species by comparative proteogenomics" @default.
- W3089551412 cites W1877854700 @default.
- W3089551412 cites W1905504015 @default.
- W3089551412 cites W1971842672 @default.
- W3089551412 cites W1977829433 @default.
- W3089551412 cites W2030674374 @default.
- W3089551412 cites W2037945751 @default.
- W3089551412 cites W2045204781 @default.
- W3089551412 cites W2047679761 @default.
- W3089551412 cites W2067480709 @default.
- W3089551412 cites W2089683981 @default.
- W3089551412 cites W2097107919 @default.
- W3089551412 cites W2113678392 @default.
- W3089551412 cites W2124820804 @default.
- W3089551412 cites W2128524551 @default.
- W3089551412 cites W2128711701 @default.
- W3089551412 cites W2128769815 @default.
- W3089551412 cites W2131271579 @default.
- W3089551412 cites W2134526812 @default.
- W3089551412 cites W2135487894 @default.
- W3089551412 cites W2140937256 @default.
- W3089551412 cites W2145159460 @default.
- W3089551412 cites W2146512944 @default.
- W3089551412 cites W2150806348 @default.
- W3089551412 cites W2165971615 @default.
- W3089551412 cites W2170551349 @default.
- W3089551412 cites W2170776626 @default.
- W3089551412 cites W2416704236 @default.
- W3089551412 cites W2512409286 @default.
- W3089551412 cites W2550084345 @default.
- W3089551412 cites W2556683337 @default.
- W3089551412 cites W2753026062 @default.
- W3089551412 cites W2755336277 @default.
- W3089551412 cites W2782311151 @default.
- W3089551412 cites W2787897791 @default.
- W3089551412 cites W2896779330 @default.
- W3089551412 cites W2913629940 @default.
- W3089551412 cites W2914997630 @default.
- W3089551412 cites W2924130156 @default.
- W3089551412 cites W2986450064 @default.
- W3089551412 cites W4234751126 @default.
- W3089551412 cites W4235583278 @default.
- W3089551412 cites W4249468678 @default.
- W3089551412 cites W4254127430 @default.
- W3089551412 doi "https://doi.org/10.1111/1462-2920.15269" @default.
- W3089551412 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7702098" @default.
- W3089551412 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33001550" @default.
- W3089551412 hasPublicationYear "2020" @default.
- W3089551412 type Work @default.
- W3089551412 sameAs 3089551412 @default.
- W3089551412 citedByCount "34" @default.
- W3089551412 countsByYear W30895514122021 @default.
- W3089551412 countsByYear W30895514122022 @default.
- W3089551412 countsByYear W30895514122023 @default.
- W3089551412 crossrefType "journal-article" @default.
- W3089551412 hasAuthorship W3089551412A5005546551 @default.
- W3089551412 hasAuthorship W3089551412A5011335306 @default.
- W3089551412 hasAuthorship W3089551412A5014776360 @default.
- W3089551412 hasAuthorship W3089551412A5054572740 @default.
- W3089551412 hasAuthorship W3089551412A5068718584 @default.
- W3089551412 hasBestOaLocation W30895514121 @default.
- W3089551412 hasConcept C100544194 @default.
- W3089551412 hasConcept C104317684 @default.
- W3089551412 hasConcept C104397665 @default.
- W3089551412 hasConcept C105176652 @default.
- W3089551412 hasConcept C141231307 @default.
- W3089551412 hasConcept C145741570 @default.
- W3089551412 hasConcept C181199279 @default.
- W3089551412 hasConcept C189206191 @default.
- W3089551412 hasConcept C2776779347 @default.
- W3089551412 hasConcept C2776979534 @default.
- W3089551412 hasConcept C2777318727 @default.
- W3089551412 hasConcept C36857842 @default.
- W3089551412 hasConcept C46111723 @default.
- W3089551412 hasConcept C523546767 @default.
- W3089551412 hasConcept C54355233 @default.
- W3089551412 hasConcept C55493867 @default.
- W3089551412 hasConcept C86803240 @default.
- W3089551412 hasConcept C89423630 @default.
- W3089551412 hasConceptScore W3089551412C100544194 @default.
- W3089551412 hasConceptScore W3089551412C104317684 @default.
- W3089551412 hasConceptScore W3089551412C104397665 @default.
- W3089551412 hasConceptScore W3089551412C105176652 @default.
- W3089551412 hasConceptScore W3089551412C141231307 @default.
- W3089551412 hasConceptScore W3089551412C145741570 @default.
- W3089551412 hasConceptScore W3089551412C181199279 @default.
- W3089551412 hasConceptScore W3089551412C189206191 @default.
- W3089551412 hasConceptScore W3089551412C2776779347 @default.
- W3089551412 hasConceptScore W3089551412C2776979534 @default.