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- W3089624672 abstract "The foundational premise for all preclinical biomedical research is that results generated from nonhumans would be predictive of and consistent with results generated in humans. Preclinical procedures have been developed to model various aspects of substance use disorder (SUD) in almost every nonhuman species, but the predominant species utilized are mice, rats, and nonhuman primates. Three common preclinical procedures that have been utilized to determine the abuse liability of novel or emerging psychoactive compounds include intracranial self-stimulation (ICSS), drug discrimination, and drug self-administration. Although all three procedures model slightly different aspects of substance abuse, all three have shown good translational concordance to predicting substance abuse potential in humans. Where these three preclinical procedures differentiate is in their utility to evaluate candidate medications for the treatment of SUDs, and preclinical drug self-administration procedures have shown to be more predictive of candidate medication treatment effects than drug discrimination endpoints. Candidate medication treatment effects on ICSS have only recently been published. Two preclinical experimental design attributes that enhance translational concordance with clinical evaluation of candidate pharmacotherapies for SUD include repeated dosing of the candidate medication over several days and assessment of behavioral selectivity for candidate medication effects to decrease drug-maintained behavior and increase behavior maintained by nondrug reinforcers such as food." @default.
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- W3089624672 date "2020-09-01" @default.
- W3089624672 modified "2023-09-26" @default.
- W3089624672 title "Preclinical Models of Substance Use Disorder" @default.
- W3089624672 doi "https://doi.org/10.1093/med/9780190920197.003.0003" @default.
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