FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3089626466> ?p ?o ?g. }

• W3089626466 abstract "Cancer cells overexpress CD47 to subvert phagocytic elimination and evade immunogenic processing of cancer antigens. Moreover, CD47 overexpression inhibits the antibody-dependent cellular phagocytosis (ADCP) and cytotoxicity (ADCC) activities of therapeutic anticancer antibodies. Consequently, CD47-blocking antibodies have been developed to overcome the immunoevasive activities of cancer cell-expressed CD47. However, the wide-spread expression of CD47 on normal cells forms a massive “antigen sink” that potentially limits sufficient tumor accretion of these antibodies. Additionally, a generalized blockade of CD47-SIRPα interaction may ultimately lead to unintended cross-presentation of self-antigens potentially promoting autoimmunity. To address these issues, we constructed a bispecific antibody, designated bsAb CD47xEGFR-IgG1, that blocks cancer cell surface-expressed CD47 in an EGFR-directed manner. BsAb CD47xEGFR-IgG1 selectively induced phagocytic removal of EGFRpos/CD47pos cancer cells and endowed neutrophils with capacity to kill these cancer cells by trogoptosis; an alternate form of ADCC that disrupts the target cell membrane. Importantly, bsAb CD47xEGFR-IgG1 selectively enhanced phagocytosis and immunogenic processing of EGFRpos/CD47pos cancers cells ectopically expressing viral protein CMVpp65.In conclusion, bsAb CD47xEGFR-IgG1 may be useful to reduce on-target/off-tumor effects of CD47-blocking approaches, enhance cancer cell elimination by trogoptosis, and promote adaptive anticancer immune responses." @default.
• W3089626466 created "2020-10-08" @default.
• W3089626466 creator A5019749108 @default.
• W3089626466 creator A5039055014 @default.
• W3089626466 creator A5045254285 @default.
• W3089626466 creator A5051758223 @default.
• W3089626466 creator A5072705437 @default.
• W3089626466 creator A5077315286 @default.
• W3089626466 creator A5039422719 @default.
• W3089626466 date "2020-01-01" @default.
• W3089626466 modified "2023-10-16" @default.
• W3089626466 title "Bispecific antibody approach for EGFR-directed blockade of the CD47-SIRPα “don’t eat me” immune checkpoint promotes neutrophil-mediated trogoptosis and enhances antigen cross-presentation" @default.
• W3089626466 cites W1907947122 @default.
• W3089626466 cites W1966217032 @default.
• W3089626466 cites W1996110290 @default.
• W3089626466 cites W2023977540 @default.
• W3089626466 cites W2025670857 @default.
• W3089626466 cites W2026809196 @default.
• W3089626466 cites W2031211461 @default.
• W3089626466 cites W2053602716 @default.
• W3089626466 cites W2057936669 @default.
• W3089626466 cites W2067114333 @default.
• W3089626466 cites W2076781845 @default.
• W3089626466 cites W2083997681 @default.
• W3089626466 cites W2091133773 @default.
• W3089626466 cites W2096876043 @default.
• W3089626466 cites W2097733789 @default.
• W3089626466 cites W2103746815 @default.
• W3089626466 cites W2106545303 @default.
• W3089626466 cites W2106905367 @default.
• W3089626466 cites W2108124504 @default.
• W3089626466 cites W2124054226 @default.
• W3089626466 cites W2130869560 @default.
• W3089626466 cites W2133346943 @default.
• W3089626466 cites W2133725847 @default.
• W3089626466 cites W2140766170 @default.
• W3089626466 cites W2205886515 @default.
• W3089626466 cites W2592323349 @default.
• W3089626466 cites W2763960561 @default.
• W3089626466 cites W2795318100 @default.
• W3089626466 cites W2800073762 @default.
• W3089626466 cites W2811247652 @default.
• W3089626466 cites W2899044337 @default.
• W3089626466 cites W2984919788 @default.
• W3089626466 cites W3003570359 @default.
• W3089626466 doi "https://doi.org/10.1080/2162402x.2020.1824323" @default.
• W3089626466 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7714490" @default.
• W3089626466 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33299654" @default.
• W3089626466 hasPublicationYear "2020" @default.
• W3089626466 type Work @default.
• W3089626466 sameAs 3089626466 @default.
• W3089626466 citedByCount "24" @default.
• W3089626466 countsByYear W30896264662021 @default.
• W3089626466 countsByYear W30896264662022 @default.
• W3089626466 countsByYear W30896264662023 @default.
• W3089626466 crossrefType "journal-article" @default.
• W3089626466 hasAuthorship W3089626466A5019749108 @default.
• W3089626466 hasAuthorship W3089626466A5039055014 @default.
• W3089626466 hasAuthorship W3089626466A5039422719 @default.
• W3089626466 hasAuthorship W3089626466A5045254285 @default.
• W3089626466 hasAuthorship W3089626466A5051758223 @default.
• W3089626466 hasAuthorship W3089626466A5072705437 @default.
• W3089626466 hasAuthorship W3089626466A5077315286 @default.
• W3089626466 hasBestOaLocation W30896264661 @default.
• W3089626466 hasConcept C121608353 @default.
• W3089626466 hasConcept C147483822 @default.
• W3089626466 hasConcept C159654299 @default.
• W3089626466 hasConcept C160448771 @default.
• W3089626466 hasConcept C203014093 @default.
• W3089626466 hasConcept C2776090121 @default.
• W3089626466 hasConcept C2777701055 @default.
• W3089626466 hasConcept C2780104668 @default.
• W3089626466 hasConcept C2780674031 @default.
• W3089626466 hasConcept C2780851360 @default.
• W3089626466 hasConcept C40677261 @default.
• W3089626466 hasConcept C45121317 @default.
• W3089626466 hasConcept C502942594 @default.
• W3089626466 hasConcept C542903549 @default.
• W3089626466 hasConcept C54355233 @default.
• W3089626466 hasConcept C83464605 @default.
• W3089626466 hasConcept C86803240 @default.
• W3089626466 hasConcept C8891405 @default.
• W3089626466 hasConcept C96232424 @default.
• W3089626466 hasConceptScore W3089626466C121608353 @default.
• W3089626466 hasConceptScore W3089626466C147483822 @default.
• W3089626466 hasConceptScore W3089626466C159654299 @default.
• W3089626466 hasConceptScore W3089626466C160448771 @default.
• W3089626466 hasConceptScore W3089626466C203014093 @default.
• W3089626466 hasConceptScore W3089626466C2776090121 @default.
• W3089626466 hasConceptScore W3089626466C2777701055 @default.
• W3089626466 hasConceptScore W3089626466C2780104668 @default.
• W3089626466 hasConceptScore W3089626466C2780674031 @default.
• W3089626466 hasConceptScore W3089626466C2780851360 @default.
• W3089626466 hasConceptScore W3089626466C40677261 @default.
• W3089626466 hasConceptScore W3089626466C45121317 @default.
• W3089626466 hasConceptScore W3089626466C502942594 @default.
• W3089626466 hasConceptScore W3089626466C542903549 @default.
• W3089626466 hasConceptScore W3089626466C54355233 @default.
• W3089626466 hasConceptScore W3089626466C83464605 @default.
• W3089626466 hasConceptScore W3089626466C86803240 @default.

• next