Matches in SemOpenAlex for { <https://semopenalex.org/work/W3089629346> ?p ?o ?g. }
- W3089629346 endingPage "1800" @default.
- W3089629346 startingPage "1790" @default.
- W3089629346 abstract "Aims Donor's CYP3A‐status ( CYP3A5 genotype and CYP3A4 expression) can provide prognostic information regarding tacrolimus‐metabolizing capacity of the liver graft and initial tacrolimus dosing for therapeutic blood concentrations in liver transplants. The present work prospectively investigated whether CYP3A‐status guided tacrolimus therapy has any potential clinical benefit for recipients in the early postoperative period. Methods The contribution of preliminary assaying of donor CYP3A‐status to the optimization of initial tacrolimus therapy and to the reduction of adverse events (acute rejection, infection, nephrotoxicity) was investigated in 112 liver transplant recipients (CYPtest group) comparing to 101 control patients on tacrolimus concentration guided therapy. Results The time for achieving therapeutic tacrolimus concentration was significantly reduced, confirming potential benefit of initial tacrolimus therapy adjusted to donor's CYP3A‐status over classical clinical practice of tacrolimus concentration guided treatment (4 vs 8 days, P < 0.0001). Acute rejection episodes (3.6 vs 23.8%, P < 0.0001) and tacrolimus induced nephrotoxicity (8 vs 27%, P = 0.0004) were less frequent in CYPtest group than in control patients, whereas occurrence of infectious disease was not influenced by tacrolimus dosing strategy (3.6 vs 5.9% in CYPtest and control groups, P > 0.05). Acute rejection was often accompanied with tacrolimus blood concentrations lower than 10 ng mL −1 (20/24 of control and 2/4 of CYPtest patients), while nephrotoxicity was associated with high tacrolimus concentrations (>20 ng mL −1 ) in the first week after transplantation (13/27 of control and 2/9 of CYPtest patients). Conclusion CYP3A‐status guided therapy significantly improved the risk of misdosing induced early adverse effects (acute rejection, nephrotoxicity)." @default.
- W3089629346 created "2020-10-08" @default.
- W3089629346 creator A5007028954 @default.
- W3089629346 creator A5007929880 @default.
- W3089629346 creator A5016681824 @default.
- W3089629346 creator A5031791058 @default.
- W3089629346 creator A5038212665 @default.
- W3089629346 creator A5043235077 @default.
- W3089629346 creator A5051978620 @default.
- W3089629346 creator A5061824974 @default.
- W3089629346 creator A5064403237 @default.
- W3089629346 creator A5066067485 @default.
- W3089629346 creator A5087326762 @default.
- W3089629346 creator A5087736632 @default.
- W3089629346 date "2020-11-02" @default.
- W3089629346 modified "2023-10-18" @default.
- W3089629346 title "Clinical significance of personalized tacrolimus dosing by adjusting to donor CYP3A‐status in liver transplant recipients" @default.
- W3089629346 cites W1052765 @default.
- W3089629346 cites W1581908208 @default.
- W3089629346 cites W1882474387 @default.
- W3089629346 cites W1967670996 @default.
- W3089629346 cites W1968726492 @default.
- W3089629346 cites W1978692962 @default.
- W3089629346 cites W1980412428 @default.
- W3089629346 cites W1981109640 @default.
- W3089629346 cites W1984804773 @default.
- W3089629346 cites W1989480016 @default.
- W3089629346 cites W1991267023 @default.
- W3089629346 cites W2006176801 @default.
- W3089629346 cites W2010427019 @default.
- W3089629346 cites W2011562131 @default.
- W3089629346 cites W2019451182 @default.
- W3089629346 cites W2026630188 @default.
- W3089629346 cites W2027648297 @default.
- W3089629346 cites W2031400172 @default.
- W3089629346 cites W2031915073 @default.
- W3089629346 cites W2033139608 @default.
- W3089629346 cites W2034790296 @default.
- W3089629346 cites W2038421635 @default.
- W3089629346 cites W2044140426 @default.
- W3089629346 cites W2045331140 @default.
- W3089629346 cites W2054526297 @default.
- W3089629346 cites W2056593533 @default.
- W3089629346 cites W2060549976 @default.
- W3089629346 cites W2066404985 @default.
- W3089629346 cites W2067430899 @default.
- W3089629346 cites W2076662121 @default.
- W3089629346 cites W2080242218 @default.
- W3089629346 cites W2089077571 @default.
- W3089629346 cites W2118861690 @default.
- W3089629346 cites W2136728678 @default.
- W3089629346 cites W2139090295 @default.
- W3089629346 cites W2143550409 @default.
- W3089629346 cites W2167068575 @default.
- W3089629346 cites W2235002440 @default.
- W3089629346 cites W2328701038 @default.
- W3089629346 cites W2413053425 @default.
- W3089629346 cites W2433496571 @default.
- W3089629346 cites W2482615115 @default.
- W3089629346 cites W2564297398 @default.
- W3089629346 cites W2615904154 @default.
- W3089629346 cites W2766994944 @default.
- W3089629346 cites W2767575214 @default.
- W3089629346 cites W2785259657 @default.
- W3089629346 cites W2794306199 @default.
- W3089629346 cites W2807235816 @default.
- W3089629346 cites W2862412298 @default.
- W3089629346 cites W2884848108 @default.
- W3089629346 cites W2894092623 @default.
- W3089629346 cites W2942673049 @default.
- W3089629346 cites W2945129756 @default.
- W3089629346 cites W2953274239 @default.
- W3089629346 cites W2969596195 @default.
- W3089629346 cites W4233901727 @default.
- W3089629346 cites W4247204813 @default.
- W3089629346 cites W4256071109 @default.
- W3089629346 doi "https://doi.org/10.1111/bcp.14566" @default.
- W3089629346 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32986876" @default.
- W3089629346 hasPublicationYear "2020" @default.
- W3089629346 type Work @default.
- W3089629346 sameAs 3089629346 @default.
- W3089629346 citedByCount "4" @default.
- W3089629346 countsByYear W30896293462021 @default.
- W3089629346 countsByYear W30896293462022 @default.
- W3089629346 countsByYear W30896293462023 @default.
- W3089629346 crossrefType "journal-article" @default.
- W3089629346 hasAuthorship W3089629346A5007028954 @default.
- W3089629346 hasAuthorship W3089629346A5007929880 @default.
- W3089629346 hasAuthorship W3089629346A5016681824 @default.
- W3089629346 hasAuthorship W3089629346A5031791058 @default.
- W3089629346 hasAuthorship W3089629346A5038212665 @default.
- W3089629346 hasAuthorship W3089629346A5043235077 @default.
- W3089629346 hasAuthorship W3089629346A5051978620 @default.
- W3089629346 hasAuthorship W3089629346A5061824974 @default.
- W3089629346 hasAuthorship W3089629346A5064403237 @default.
- W3089629346 hasAuthorship W3089629346A5066067485 @default.
- W3089629346 hasAuthorship W3089629346A5087326762 @default.
- W3089629346 hasAuthorship W3089629346A5087736632 @default.