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• W3089662922 abstract "Background Pityriasis rubra pilaris (PRP) is a rare chronic inflammatory dermatosis. Treatment is challenging and mostly based on scarce empirical evidence from large case series. Objective To investigate patient characteristics and therapy outcomes in patients with PRP. Materials & methods In this retrospective study, patients with PRP treated at the Department of Dermatology, University Medical Center Gottingen, between 01/2005 and 10/2018, were analysed according to patient and disease characteristics and treatment experience. Results PRP was diagnosed in 28 patients with a mean age of 57.3 years at onset; 20 were men (71.4%) and eight women (28.6%). Of all the patients, 89.3% had comorbid diseases; metabolic disorders were particularly frequent. Seventy-eight treatment courses were identified with acitretin as the most common therapy (28.2%). Excellent response was noted in 71.4% of treatment courses with methotrexate, followed by cyclosporine (27.3%) and acitretin (19.0%). Among biologics, ustekinumab (excellent response: 75.0%) and infliximab (50.0%) were particularly effective. Conclusion This study is one of the few comprehensive larger case series of patients with PRP. Acitretin may be effective, particularly for type I PRP, and other retinoids, methotrexate or cyclosporine might also be considered early in the therapeutic algorithm. Moreover, our data adds to the growing evidence that biologics are effective and safe for the treatment of PRP." @default.
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• W3089662922 date "2020-10-01" @default.
• W3089662922 modified "2023-09-30" @default.
• W3089662922 title "Treatment of pityriasis rubra pilaris: a case series of 28 patients" @default.
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• W3089662922 doi "https://doi.org/10.1684/ejd.2020.3879" @default.
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