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• W3089705936 abstract "Abstract Tumor-derived secretory factors orchestrate splenic hematopoietic and stromal cells to fuel metastasis. The spleen acts as a reservoir site for hematopoietic stem and progenitor cells, which are rapidly exploited as myeloid-derived suppressor cells at the cost of tumor-reactive lymphoid cells. Splenic erythroid progenitor cells and mesenchymal stromal cells contribute directly and indirectly to both tumor immune escape and the metastatic cascade. Animal models provide valuable mechanistic insights, but their translation to a clinical setting highlights specific challenges and open issues. In this review, we envision the exploitation of the spleen as a source for novel biomarkers and therapeutic approaches." @default.
• W3089705936 created "2020-10-08" @default.
• W3089705936 creator A5007044790 @default.
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• W3089705936 creator A5080974432 @default.
• W3089705936 date "2021-01-01" @default.
• W3089705936 modified "2023-10-16" @default.
• W3089705936 title "Splenic Hematopoietic and Stromal Cells in Cancer Progression" @default.
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